Primary lymphedema
MONDO:0019175A congenital condition that results in swelling in the arms or legs, and can occur during adolescence or adulthood. Loss of motion and pain may also accompany the swelling. Protein-rich lymphatic fluid accumulates in tissues, engorging and enlarging vessels and often causing visible swelling, tenderness, and pain. Left untreated, the affected tissues may continue to swell, and can become hardened or fibrotic and susceptible to infection.
Also known as: Troncular lymphatic malformation, primary lymphedema
65 clinical trials for this condition and its sub-types, 9 tagged with Primary lymphedema itself.
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Sub-types of Primary lymphedema
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Lymphatic malformation 17 trials · 55 incl. sub-types
28 sub-types
- Noonan syndrome 21 trials · 24 incl. sub-types Sub-types →
- Lymphatic malformation 5 8 trials
- Anhidrotic ectodermal dysplasia-immunodeficiency-osteopetrosis-lymphedema syndrome 4 trials
- Lymphatic malformation 12 2 trials
- MPI-congenital disorder of glycosylation 1 trial
- Deafness-lymphedema-leukemia syndrome 1 trial
- Dahlberg-Borer-Newcomer syndrome 0 trials
- Hennekam syndrome 0 trials Sub-types →
- Norman-Roberts syndrome 0 trials
- Campomelia, Cumming type 0 trials
- Congenital primary lymphedema of Gordon 0 trials
- Hypotrichosis-lymphedema-telangiectasia syndrome 0 trials
- Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 0 trials
- Lymphatic malformation 1 0 trials
- Lymphatic malformation 10 0 trials
- Lymphatic malformation 11 0 trials
- Lymphatic malformation 13 0 trials
- Lymphatic malformation 14 0 trials
- Lymphatic malformation 2 0 trials
- Lymphatic malformation 3 0 trials
- Lymphatic malformation 4 0 trials
- Lymphatic malformation 6 0 trials
- Lymphatic malformation 7 0 trials
- Lymphatic malformation 8 0 trials
- Lymphatic malformation 9 0 trials
- Lymphedema-distichiasis syndrome 0 trials
- Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability 0 trials
- Yellow nail syndrome 0 trials
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Chylous ascites 2 trials
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Aagenaes syndrome 1 trial
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German syndrome 1 trial
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2 sub-types
Most studied deeper sub-types
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Breathing exercises may boost leg lymphedema treatment
Symptom relief Recruiting nowThis study tests whether adding breathing and relaxation exercises to standard lymphedema therapy can improve walking ability and muscle oxygen levels in women with leg swelling. Participants receive either standard therapy alone or standard therapy plus a structured breathing an…
Sponsor: Toros University • Aim: Symptom relief
Last updated Jul 15, 2026 00:00 UTC
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Virtual reality steps in to help lymphedema patients walk better
Symptom relief Recruiting nowThis study tests whether adding virtual reality (VR) exercises to standard therapy can improve walking, reduce leg swelling, and boost quality of life in people with lower limb lymphedema. Forty adults with stage 2 or 3 lymphedema after cancer surgery will either receive standard…
Sponsor: Gaziler Physical Medicine and Rehabilitation Education and Research Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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Could sticky tape ease breast cancer swelling? new trial investigates
Symptom relief Recruiting nowThis study tests whether adding kinesio tape to standard therapy helps women with long-term breast or trunk swelling after breast cancer treatment. About 128 participants will receive either standard care alone or standard care plus kinesio tape for four weeks. Researchers will m…
Sponsor: Universiteit Antwerpen • Aim: Symptom relief
Last updated Jun 26, 2026 13:10 UTC
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New study tracks pregnancy dangers in rare vascular conditions
Knowledge-focused Recruiting nowThis study follows 400 pregnant women with rare blood vessel diseases (like HHT, Marfan syndrome, or lymphedema) to learn about serious pregnancy complications. Researchers will ask participants about their health during pregnancy and for 12 months after birth. The goal is to gat…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Scientists dive deep into Lymphedema's genetic roots
Knowledge-focused Recruiting nowThis study aims to understand why lymphedema develops by comparing gene activity in swollen versus healthy limbs. Researchers will take tiny tissue samples from 60 adults with primary or secondary lymphedema. The goal is to identify molecular differences that could point toward f…
Sponsor: University Hospital, Toulouse • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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Scientists probe hidden causes of stubborn leg swelling
Knowledge-focused Recruiting nowThis study looks at 48 people with chronic leg swelling to find out why some respond to compression therapy and others don't. Participants will have an MRI and genetic testing to measure fat, muscle, and fluid in their legs. The goal is to better understand the condition, not to …
Sponsor: University Hospital, Montpellier • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC