Primary lymphedema

MONDO:0019175

A congenital condition that results in swelling in the arms or legs, and can occur during adolescence or adulthood. Loss of motion and pain may also accompany the swelling. Protein-rich lymphatic fluid accumulates in tissues, engorging and enlarging vessels and often causing visible swelling, tenderness, and pain. Left untreated, the affected tissues may continue to swell, and can become hardened or fibrotic and susceptible to infection.

Also known as: Troncular lymphatic malformation, primary lymphedema

66 clinical trials for this condition and its sub-types, 9 tagged with Primary lymphedema itself.

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Where it sits in the disease tree

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↑ Lymphedema (205)

Sub-types of Primary lymphedema

Lymphatic malformation 17 trials · 56 incl. sub-types
28 sub-types
- Noonan syndrome 22 trials · 25 incl. sub-types Sub-types →
- Lymphatic malformation 5 8 trials
- Anhidrotic ectodermal dysplasia-immunodeficiency-osteopetrosis-lymphedema syndrome 4 trials
- Lymphatic malformation 12 2 trials
- MPI-congenital disorder of glycosylation 1 trial
- Deafness-lymphedema-leukemia syndrome 1 trial
- Dahlberg-Borer-Newcomer syndrome 0 trials
- Hennekam syndrome 0 trials Sub-types →
- Norman-Roberts syndrome 0 trials
- Campomelia, Cumming type 0 trials
- Congenital primary lymphedema of Gordon 0 trials
- Hypotrichosis-lymphedema-telangiectasia syndrome 0 trials
- Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 0 trials
- Lymphatic malformation 1 0 trials
- Lymphatic malformation 10 0 trials
- Lymphatic malformation 11 0 trials
- Lymphatic malformation 13 0 trials
- Lymphatic malformation 14 0 trials
- Lymphatic malformation 2 0 trials
- Lymphatic malformation 3 0 trials
- Lymphatic malformation 4 0 trials
- Lymphatic malformation 6 0 trials
- Lymphatic malformation 7 0 trials
- Lymphatic malformation 8 0 trials
- Lymphatic malformation 9 0 trials
- Lymphedema-distichiasis syndrome 0 trials
- Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability 0 trials
- Yellow nail syndrome 0 trials
Chylous ascites 2 trials
Aagenaes syndrome 1 trial
German syndrome 1 trial
CELSR1-related late-onset primary lymphedema 0 trials
EPHB4-related lymphatic-related hydrops fetalis 0 trials
GJC2-related late-onset primary lymphedema 0 trials
Aplasia cutis congenita-intestinal lymphangiectasia syndrome 0 trials
Congenital pulmonary lymphangiectasia 0 trials
Hypotrichosis-lymphedema-telangiectasia syndrome (grouping) 0 trials
2 sub-types
- Hypotrichosis-lymphedema-telangiectasia syndrome 0 trials
- Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 0 trials
Lymphedema-atrial septal defects-facial changes syndrome 0 trials
Mullerian derivatives-lymphangiectasia-polydactyly syndrome 0 trials
Warts-immunodeficiency-lymphedema-anogenital dysplasia syndrome 0 trials

Most studied deeper sub-types

Noonan syndrome 3 (2) Noonan syndrome 5 (1) Hennekam lymphangiectasia-lymphedema syndrome 1 (0) Hennekam lymphangiectasia-lymphedema syndrome 2 (0) Hennekam lymphangiectasia-lymphedema syndrome 3 (0) Noonan syndrome 1 (0) Noonan syndrome 10 (0) Noonan syndrome 11 (0) Noonan syndrome 12 (0) Noonan syndrome 13 (0) Noonan syndrome 14 (0) Noonan syndrome 2 (0) Noonan syndrome 4 (0) Noonan syndrome 6 (0) Noonan syndrome 7 (0) Noonan syndrome 8 (0) Noonan syndrome 9 (0)

Including sub-types (66) Tagged with Primary lymphedema (9)

Trials to join now! 6 Not yet recruiting 1 Completed 2

Primary lymphedema

Where it sits in the disease tree

Most studied deeper sub-types

Aerobic exercise may boost mobility in leg lymphedema patients

Is manual lymph drainage essential for leg swelling? new study investigates