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Is manual lymph drainage essential for leg swelling? new study investigates

NCT ID NCT06750679

Symptom relief Sponsor: Abant Izzet Baysal University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether adding manual lymph drainage to standard compression therapy improves outcomes for people with lower leg lymphedema. Thirty-one participants were randomly assigned to receive either compression alone or compression plus manual lymph drainage. The researchers measured fibrosis, swelling, skin thickness, and quality of life to see if the extra treatment makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Manual lymphatic drainage and compression bandage
What this could lead to
If it works, this could show that adding manual lymph drainage to compression therapy reduces fibrosis and improves quality of life for people with leg lymphedema.
What could go wrong
This is a small, completed trial with only 31 participants, so results may not apply to everyone. The benefit of manual lymph drainage over compression alone remains uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

31 people

The number who actually took part.

Started

Sep 2024

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * According to the criteria of the International Society of Lymphology Stage 2 and 3 lower extremity LE to volunteer to participate in the study * To be between the ages of 18-80 * LE involving the entire lower extremity Exclusion Criteria: * Acute deep vein thrombosis * Acute infection * Peripheral arterial disease in the lower extremity * To have systemic diseases that may cause edema other than LE (renal failure, liver failure, heart failure, etc.) * Chronic venous insufficiency * Allergy to materials used in treatment * Mental/cognitive problems that will affect cooperation * Loss of sensation * Presence of scleroderma in the treatment area * Active cancer * Radiogenic fibrosis in the treatment area

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Conditions

The condition(s) this trial relates to.

Fibrosis lymphedema primary lymphedema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lower extremity lymphedema

Contacts and locations

Locations

  • Bolu Abant Izzet Baysal University

    Bolu, Merkez, 14030, Turkey (Türkiye)

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