Primary hyperparathyroidism
MONDO:0010837Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones.
Also known as: primary hyperparathyroidism, primary hyperparathyroidism (disease)
58 clinical trials for this condition and its sub-types, 23 tagged with Primary hyperparathyroidism itself.
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Sub-types of Primary hyperparathyroidism
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Familial primary hyperparathyroidism 1 trial · 35 incl. sub-types
5 sub-types
Most studied deeper sub-types
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Old arthritis drug tested against rare tumor syndrome – but trial stalls
Disease control Stopped earlyThis study tested leflunomide, a drug used for rheumatoid arthritis, in 3 adults with MEN1 syndrome—a genetic condition that raises the risk of multiple tumors. The goal was to see if 6 months of daily leflunomide could shrink or stabilize tumors. However, the trial was terminate…
Sponsor: University Hospital, Basel, Switzerland • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Gut bugs linked to bone loss in parathyroid disease
Knowledge-focused Stopped earlyThis study looked at whether the types of bacteria in the gut can predict bone loss in people with primary hyperparathyroidism, a condition where the parathyroid glands produce too much hormone. Researchers planned to analyze gut bacteria and immune system markers in 25 patients …
Sponsor: Centre Hospitalier Universitaire Vaudois • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC