Primary erythermalgia
MONDO:0007571Primary erythermalgia is characterized by intermittent attacks of red, warm, painful burning extremities. It spontaneously arises during early childhood and adolescence in the absence of any detectable underlying disorder.
Also known as: PERYTHM, primary erythromelalgia, Mitchell disease (formerly), erythermalgia, primary, erythromelalgia, familial, erythromelalgia, primary, neuropathy, small fiber, neuropathy, small fibre
13 clinical trials for this condition and its sub-types, 8 tagged with Primary erythermalgia itself.
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Gene therapy targets chronic nerve pain in new trial
Disease control Recruiting nowThis study tests a one-time gene therapy called ST-503 for people with chronic pain from small fiber neuropathy that hasn't improved with standard treatments. The therapy aims to block pain signals before they reach the brain. The trial involves 27 adults and compares the gene th…
Phase 1/2 • Sponsor: Sangamo Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Could immune therapy ease nerve pain? new trial tests IVIG for small fiber neuropathy
Disease control Recruiting nowThis study tests whether a drug called IVIG (Panzyga) can help people with small fiber neuropathy, a condition causing nerve pain and damage. Researchers will give 20 adults either IVIG or a placebo for 6 months, then check nerve fiber growth in skin biopsies and pain levels. The…
Phase 2 • Sponsor: Endeavor Health • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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Can magnetic pulses to the brain quiet nerve pain?
Symptom relief Recruiting nowSmall fiber neuropathy damages tiny nerve fibers, causing severe pain that often resists standard painkillers. This trial tests whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive technique that sends magnetic pulses to specific brain regions, can reduce t…
Sponsor: Maastricht University Medical Center • Aim: Symptom relief
Last updated Sep 21, 2026 19:00 UTC
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Hidden nerve pain in Sjögren's: study reveals true toll on life and wallet
Knowledge-focused Recruiting nowThis study looks at how small fiber neuropathy (nerve damage causing pain, burning, and numbness) impacts the quality of life and medical costs for people with Sjögren's syndrome. Researchers will follow 100 adults with Sjögren's to measure their symptoms, daily functioning, and …
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC