Primary ciliary dyskinesia
MONDO:0016575A rare, genetically heterogeneous, primarily respiratory disorder characterized by chronic upper and lower respiratory tract disease. Approximately half of PCD patients have an organ laterality defect (situs inversus totalis or situs ambiguus/heterotaxy).
Also known as: Kartagener syndrome, Kartagener's syndrome, PCD, Dextrocardia bronchiectasis and sinusitis, Dextrocardia-bronchiectasis-sinusitis syndrome, ICS, Immotile cilia syndrome, Kartagener type, Primary ciliary dyskinesia and situs inversus
34 clinical trials for this condition and its sub-types, 34 tagged with Primary ciliary dyskinesia itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Primary ciliary dyskinesia
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Primary ciliary dyskinesia 1 6 trials
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Stromme syndrome 0 trials
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Ciliary dyskinesia, primary, 37 0 trials
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Ciliary dyskinesia, primary, 38 0 trials
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Ciliary dyskinesia, primary, 39 0 trials
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Ciliary dyskinesia, primary, 40 0 trials
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Ciliary dyskinesia, primary, 41 0 trials
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Ciliary dyskinesia, primary, 42 0 trials
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Ciliary dyskinesia, primary, 43 0 trials
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Ciliary dyskinesia, primary, 44 0 trials
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Ciliary dyskinesia, primary, 45 0 trials
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Ciliary dyskinesia, primary, 46 0 trials
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Ciliary dyskinesia, primary, 50 0 trials
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Ciliary dyskinesia, primary, 51 0 trials
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Ciliary dyskinesia, primary, 52 0 trials
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Ciliary dyskinesia, primary, 53 0 trials
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Ciliary dyskinesia, primary, 54 0 trials
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Primary ciliary dyskinesia 10 0 trials
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Primary ciliary dyskinesia 11 0 trials
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Primary ciliary dyskinesia 12 0 trials
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Primary ciliary dyskinesia 13 0 trials
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Primary ciliary dyskinesia 14 0 trials
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Primary ciliary dyskinesia 15 0 trials
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Primary ciliary dyskinesia 16 0 trials
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Primary ciliary dyskinesia 17 0 trials
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Primary ciliary dyskinesia 18 0 trials
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Primary ciliary dyskinesia 19 0 trials
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Primary ciliary dyskinesia 2 0 trials
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Primary ciliary dyskinesia 20 0 trials
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Primary ciliary dyskinesia 21 0 trials
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Primary ciliary dyskinesia 22 0 trials
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Primary ciliary dyskinesia 23 0 trials
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Primary ciliary dyskinesia 24 0 trials
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Primary ciliary dyskinesia 26 0 trials
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Primary ciliary dyskinesia 27 0 trials
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Primary ciliary dyskinesia 28 0 trials
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Primary ciliary dyskinesia 29 0 trials
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Primary ciliary dyskinesia 3 0 trials
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Primary ciliary dyskinesia 30 0 trials
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Primary ciliary dyskinesia 32 0 trials
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Primary ciliary dyskinesia 33 0 trials
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Primary ciliary dyskinesia 34 0 trials
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Primary ciliary dyskinesia 35 0 trials
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Primary ciliary dyskinesia 4 0 trials
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Primary ciliary dyskinesia 5 0 trials
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Primary ciliary dyskinesia 6 0 trials
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Primary ciliary dyskinesia 7 0 trials
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Primary ciliary dyskinesia 8 0 trials
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Primary ciliary dyskinesia 9 0 trials
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Inhaled mRNA therapy shows promise for rare lung disease
Disease control CompletedThis early-phase trial tested an inhaled mRNA therapy called RCT1100 in 14 adults with primary ciliary dyskinesia (PCD) caused by a specific genetic mutation (DNAI1). The goal was to see if the treatment could improve mucociliary clearance — the lungs' ability to clear mucus and …
Phase 1 • Sponsor: ReCode Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
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Experimental mRNA inhalation therapy targets rare lung disease
Disease control CompletedThis early-phase study tests an inhaled mRNA therapy called RCT1100 in 7 adults with primary ciliary dyskinesia caused by DNAI1 gene mutations. The goal is to see if the treatment is safe and can help restore ciliary function in the lungs. It is a small, open-label trial focused …
Phase 1 • Sponsor: ReCode Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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NIH study aims to unlock secrets of lung mucus diseases
Knowledge-focused CompletedThis completed study looked at people with genetic conditions that affect how the lungs clear mucus, such as cystic fibrosis and primary ciliary dyskinesia. Researchers examined 87 participants, including healthy volunteers, to understand why these patients get repeated lung infe…
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:08 UTC
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Rare lung disease study aims to uncover key health markers
Knowledge-focused CompletedThis completed study observed 31 adults with primary ciliary dyskinesia (PCD), a rare lung condition, along with healthy volunteers. Researchers measured lung function, mucus clearance, and lung structure using tests like spirometry and CT scans. The goal was to better understand…
Sponsor: ReCode Therapeutics • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Study reveals hidden differences in Kids' lung diseases during exercise
Knowledge-focused CompletedThis completed study looked at 88 children with cystic fibrosis (CF) or primary ciliary dyskinesia (PCD) to compare how well they can exercise, how their muscles use oxygen, and how strong their breathing muscles are. Researchers used walking tests and muscle oxygen monitors to m…
Sponsor: Gazi University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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Study aims to map respiratory attacks in rare lung disease
Knowledge-focused CompletedThis completed study followed 105 children and adults with primary ciliary dyskinesia (PCD), a rare lung condition, to track how their breathing and quality of life change during respiratory flare-ups. Researchers measured lung function, symptoms, and daily impacts to gather info…
Sponsor: University of North Carolina, Chapel Hill • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC
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Study reveals how lung diseases affect Kids' arm strength and balance
Knowledge-focused CompletedThis completed study looked at how well children with cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) can use their arms for exercise, how their muscles use oxygen, and their balance. Researchers compared 88 children aged 6-18 with CF, PCD, and healthy peers. The goal w…
Sponsor: Gazi University • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:50 UTC
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Gene clues may predict lung function in rare disease
Knowledge-focused CompletedThis study looked at how well people with Primary Ciliary Dyskinesia (PCD) clear mucus from their lungs, based on which gene mutation they have. Researchers measured lung clearance in 27 participants, including healthy volunteers and PCD patients with different genetic mutations.…
Early phase 1 • Sponsor: University of North Carolina, Chapel Hill • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:24 UTC