Preretinal fibrosis
MONDO:0002174A membrane on the vitreal surface of the retina resulting from the proliferation of one or more of three retinal elements: (1) fibrous astrocytes; (2) fibrocytes; and (3) retinal pigment epithelial cells. Localized epiretinal membranes may occur at the posterior pole of the eye without clinical signs or may cause marked loss of vision as a result of covering, distorting, or detaching the fovea centralis. Epiretinal membranes may cause vascular leakage and secondary retinal edema. In younger individuals some membranes appear to be developmental in origin and occur in otherwise normal eyes. The majority occur in association with retinal holes, ocular concussions, retinal inflammation, or after ocular surgery. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p291)
Also known as: macular puckering of retina
35 clinical trials for this condition and its sub-types, 21 tagged with Preretinal fibrosis itself.
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Can a patch of your own retina restore clearer vision?
Disease control Not yet recruitingThis trial tests a new surgical technique for people with an epiretinal membrane, a condition where abnormal tissue grows on the retina and blurs or distorts vision. The standard treatment is to peel off this membrane, but the retina may not fully heal. The new approach uses a sm…
Sponsor: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine • Aim: Disease control
Last updated Aug 20, 2026 00:00 UTC
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Can a new lens design sharpen vision after macular surgery?
Symptom relief Not yet recruitingThis trial tests whether an extended depth of focus (EDOF) lens, which aims to improve vision at multiple distances, works better than a standard monofocal lens in people who need both cataract and epiretinal membrane surgery. The study enrolls 100 adults with an epiretinal membr…
Sponsor: Almaviva Sante • Aim: Symptom relief
Last updated Aug 29, 2026 00:00 UTC
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New eye camera could spot retinal disease earlier
Knowledge-focused Not yet recruitingThis study will test a new, noninvasive camera called XyCAM CRE that measures blood flow in the back of the eye. Researchers will compare its images with standard eye tests in 350 adults with retinal disorders. The goal is to see if this camera can provide extra information to he…
Sponsor: Stuart Terry Eye Associates • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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AI vs. human eye: study tests if smart software improves retinal reports
Knowledge-focused Not yet recruitingThis study looks at whether giving eye doctors AI-generated measurements from retinal images helps them write more accurate and complete reports. About 29 ophthalmologists and trainees will be randomly assigned to use AI tools or just the original images. A panel of senior expert…
Sponsor: Beijing Tongren Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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Diabetic eye patients at risk for extra retinal scarring?
Knowledge-focused Not yet recruitingThis study will look at 225 adults with diabetic retinopathy to find out how many also develop an epiretinal membrane — a thin, scar-like layer on the retina that can blur vision. Researchers will use eye scans to detect the membrane and check for related factors like age, diabet…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC