Premature aging syndrome
MONDO:0019303Changes in the organism associated with senescence, occurring at an accelerated rate.
Also known as: premature ageing, premature aging
109 clinical trials for this condition and its sub-types, 6 tagged with Premature aging syndrome itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Premature aging syndrome
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Telomere syndrome 9 trials · 92 incl. sub-types
7 sub-types
- Cirrhosis, familial 4 trials · 79 incl. sub-types Sub-types →
- Nodular regenerative hyperplasia of the liver 3 trials
- Immunodeficiency-centromeric instability-facial anomalies syndrome 1 trial Sub-types →
- Pulmonary fibrosis and/or bone marrow failure, telomere-related 1 trial Sub-types →
- ACD-related telomere biology disorder 0 trials Sub-types →
- Coats plus syndrome 0 trials Sub-types →
- Dyskeratosis congenita, autosomal dominant 1 0 trials
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Progeroid syndrome 3 trials · 11 incl. sub-types
16 sub-types
- Cockayne syndrome 6 trials Sub-types →
- Hutchinson-Gilford progeria syndrome 3 trials
- Werner syndrome 2 trials
- Fischer-Zirnsak progeroid syndrome 0 trials
- Fontaine progeroid syndrome 0 trials
- Garg-Mishra progeroid syndrome 0 trials
- Marbach-Rustad progeroid syndrome 0 trials
- Nestor-Guillermo progeria syndrome 0 trials
- RECON progeroid syndrome 0 trials
- Wiedemann-Rautenstrauch syndrome 0 trials
- XFE progeroid syndrome 0 trials
- Achalasia-progeroid syndrome 0 trials
- Mandibular hypoplasia-deafness-progeroid syndrome 0 trials
- Mandibuloacral dysplasia progeroid syndrome 0 trials
- Progeroid and marfanoid aspect-lipodystrophy syndrome 0 trials
- Progeroid facial appearance with hand anomalies 0 trials
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Flynn-Aird syndrome 0 trials
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Acrogeria 0 trials
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De Barsy syndrome 0 trials
2 sub-types
- ALDH18A1-related de Barsy syndrome 0 trials
- PYCR1-related de Barsy syndrome 0 trials
Most studied deeper sub-types
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New combo therapy shows promise in early sarcoma trial
Disease control Stopped earlyThis study tests a new drug (ADI-PEG 20) combined with chemotherapy and radiation before surgery for soft tissue sarcoma. The goal is to find the safest dose and see how well it shrinks tumors. Only 6 patients with intermediate or high-grade sarcoma of the trunk or limbs are taki…
Phase 1 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Sep 05, 2026 00:00 UTC
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New combo therapy aimed at Hard-to-Treat liver disease
Disease control Stopped earlyThis study tested whether combining two drugs, obeticholic acid and bezafibrate, could improve liver health in people with primary biliary cholangitis (PBC) who did not respond well to or could not take the standard medicine. The trial enrolled 75 adults and measured changes in a…
Phase 2 • Sponsor: Intercept Pharmaceuticals • Aim: Disease control
Last updated Jul 18, 2026 00:00 UTC
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PBC drug combo safety check ends early
Disease control Stopped earlyThis study looked at the long-term safety of a fixed-dose combination of two drugs (obeticholic acid and bezafibrate) for people with primary biliary cholangitis (PBC), a chronic liver disease. It enrolled 62 adults who had already been taking the combination in earlier studies. …
Phase 3 • Sponsor: Intercept Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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Blood test may tame the tightrope walk of transplant drugs
Diagnosis Stopped earlyThis study tests whether a blood test called TruGraf can help doctors fine-tune immunosuppression medications in liver transplant recipients with autoimmune liver diseases like autoimmune hepatitis, primary sclerosing cholangitis, or primary biliary cirrhosis. The test measures g…
Sponsor: Washington University School of Medicine • Aim: Diagnosis
Last updated Aug 09, 2026 00:00 UTC
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Ear device aims to cut opioid use after liver transplant
Symptom relief Stopped earlyThis study tested a small device worn on the ear that uses mild electrical pulses to help control pain after a liver transplant. The goal was to see if it could reduce the need for strong painkillers like opioids. The study was stopped early and included 27 adults waiting for a l…
Sponsor: Duke University • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC