Precancerous condition
MONDO:0021074A pathological process with signs indicating it may become cancerous. Representative examples include leukoplakia, dysplastic nevus, actinic keratosis, xeroderma pigmentosum, and intraepithelial neoplasia.
Also known as: precancerous condition, precancerous state, premalignant condition, premalignant state
518 clinical trials for this condition and its sub-types, 51 tagged with Precancerous condition itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Precancerous condition
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In situ carcinoma 25 trials · 318 incl. sub-types
21 sub-types
- Breast carcinoma in situ 76 trials · 204 incl. sub-types Sub-types →
- Adenocarcinoma in situ 10 trials · 170 incl. sub-types Sub-types →
- Bladder carcinoma in situ 30 trials
- Intestine carcinoma in situ 0 trials · 16 incl. sub-types Sub-types →
- Uterus carcinoma in situ 0 trials · 16 incl. sub-types Sub-types →
- Esophagus carcinoma in situ 13 trials
- Squamous carcinoma in situ 5 trials · 10 incl. sub-types Sub-types →
- Skin carcinoma in situ 3 trials · 9 incl. sub-types Sub-types →
- Oral cavity carcinoma in situ 5 trials Sub-types →
- Stomach carcinoma in situ 4 trials Sub-types →
- Lung carcinoma in situ 2 trials · 3 incl. sub-types Sub-types →
- Pharynx carcinoma in situ 0 trials · 2 incl. sub-types Sub-types →
- Larynx carcinoma in situ 1 trial Sub-types →
- Carcinoma in situ of ureter 0 trials
- Carcinoma in situ of urethra 0 trials
- Eye carcinoma in situ 0 trials
- Gall bladder carcinoma in situ 0 trials
- Grade III prostatic intraepithelial neoplasia 0 trials
- Kidney carcinoma in situ 0 trials Sub-types →
- Liver carcinoma in situ 0 trials Sub-types →
- Nasal cavity carcinoma in situ 0 trials
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Intraepithelial neoplasia 25 trials · 71 incl. sub-types
3 sub-types
- Squamous cell intraepithelial neoplasia 26 trials · 43 incl. sub-types Sub-types →
- Prostate intraepithelial neoplasia 2 trials Sub-types →
- Small intestinal intraepithelial neoplasia 1 trial
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Pre-malignant neoplasm 2 trials · 43 incl. sub-types
1 sub-type
- Actinic keratosis 41 trials
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Leukoplakia 7 trials · 28 incl. sub-types
5 sub-types
- Oral mucosa leukoplakia 23 trials Sub-types →
- Esophageal leukoplakia 1 trial
- Leukoplakia of penis 0 trials
- Leukoplakia of vagina 0 trials
- Uterine cervix leukoplakia 0 trials
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Premalignant hematological system disease 3 trials · 25 incl. sub-types
2 sub-types
- Clonal hematopoiesis 10 trials · 22 incl. sub-types Sub-types →
- Atypical lymphoproliferative disorder 0 trials
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Gastric intestinal metaplasia 18 trials
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Preneoplastic lesion 8 trials
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Neoplastic polyp 1 trial · 5 incl. sub-types
1 sub-type
- Polyposis 3 trials · 4 incl. sub-types Sub-types →
Most studied deeper sub-types
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Inhaled gene therapy takes aim at lung nodules
Disease control Not yet recruitingThis study tests a gene therapy called Gendicine, given as a mist to breathe in, for people with multiple ground-glass lung nodules — spots that may turn into cancer. About 38 adults will receive the treatment and be monitored with CT scans to see if the nodules shrink or disappe…
Phase 2 • Sponsor: The First Affiliated Hospital of Guangzhou Medical University • Aim: Disease control
Last updated Jun 26, 2026 13:05 UTC
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Blood test may spot vocal cord cancer early
Diagnosis Not yet recruitingThis study looks at whether certain blood inflammation markers can help doctors tell the difference between harmless, precancerous, and cancerous vocal cord growths. Researchers will check medical records of 250 adults who have been diagnosed with a vocal cord lesion. The goal is…
Sponsor: Antalya Health Sciences University • Aim: Diagnosis
Last updated Jun 27, 2026 13:05 UTC
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Sniffing out cancer: new breath test could spot colon cancer before it spreads
Diagnosis Not yet recruitingThis study tests a new, non-invasive method to detect colorectal cancer and precancerous growths by analyzing odors from breath and intestinal gas. About 453 participants—including people with colorectal cancer, precancerous lesions, and healthy volunteers—will provide samples an…
Sponsor: Beijing University of Chinese Medicine • Aim: Diagnosis
Last updated Jun 27, 2026 13:01 UTC
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AI lends a hand in the operating room to stop bleeding faster
Symptom relief Not yet recruitingThis study tests whether a real-time artificial intelligence system can help doctors find and stop bleeding faster during a minimally invasive surgery called endoscopic submucosal dissection (ESD), used to remove early-stage digestive tract cancers. About 160 patients will be ran…
Sponsor: Qilu Hospital of Shandong University • Aim: Symptom relief
Last updated Sep 05, 2026 00:00 UTC
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New camera mode may speed up gut cancer surgery
Symptom relief Not yet recruitingThis study tests whether a special imaging mode called RDI helps doctors remove early-stage cancers from the stomach, esophagus, or colon more quickly and safely than standard white-light endoscopy. About 158 adults with early cancers or precancerous lesions will be randomly assi…
Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University • Aim: Symptom relief
Last updated Jun 27, 2026 08:14 UTC
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Blood test may spare thousands from unnecessary colon surgery
Knowledge-focused Not yet recruitingThis study will collect blood samples from 1,000 people with small colon growths to see if a liquid biopsy can accurately tell benign from malignant lesions and predict cancer spread to lymph nodes. Current methods often lead to unnecessary surgery. The goal is to create a bioban…
Sponsor: University Hospital, Montpellier • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Scientists map cell types in oral cancer to unlock early detection
Knowledge-focused Not yet recruitingThis study aims to understand the different cell types in oral cancer and pre-cancerous mouth lesions. Researchers will analyze tissue and blood samples from 150 participants to map gene activity and cell interactions. They will also test whether a simple brush sample can replace…
Sponsor: Centre Leon Berard • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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Could a simple test spot colon cancer early? new study investigates
Knowledge-focused Not yet recruitingThis study will examine genetic changes in colon polyps and stool samples from 32 Korean adults to find markers that could help detect colon cancer earlier. Researchers will compare DNA methylation levels in polyp tissue versus normal tissue. The goal is to improve screening and …
Sponsor: Bundang CHA Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC