Pouchitis

This trial tests whether fecal microbiota transplant (FMT) — transferring stool from a healthy donor pouch into an inflamed one — can safely ease chronic pouchitis, a complication after ulcerative colitis surgery. Participants first take antibiotics and a bowel prep, then receive…

This study tests whether vedolizumab (Entyvio) can improve symptoms and reduce inflammation in children with chronic pouchitis, a condition where an internal pouch becomes inflamed after bowel surgery. About 30 children will receive up to 12 infusions over 82 weeks. The main goal…

This study tests whether the drug guselkumab (Tremfya), with or without a low-processed-food diet, can help people with chronic pouchitis—a painful gut condition that can occur after surgery for ulcerative colitis. Twenty adults who have not responded to antibiotics will receive …

This study tests whether mirikizumab (Omvoh) can reduce symptoms of chronic pouchitis, a condition where the internal pouch created after colon surgery becomes inflamed. Twenty-five adults will receive the drug every four weeks for a year. Researchers will track symptom changes u…

This study tests whether Aquamin, a natural mineral supplement from seaweed, can prevent pouchitis—a painful inflammation of the J-pouch—in people with ulcerative colitis who have had their colon removed. About 52 participants will take Aquamin or a placebo for up to 8 months. Th…

This trial tests whether taking the antibiotic rifaximin daily for a year can prevent recurrent pouchitis—inflammation of the J-pouch—after an initial episode in people who had surgery for ulcerative colitis. All participants will receive rifaximin twice a day for up to 365 days.…

This study tests whether the drug etrasimod can prevent pouchitis, a common inflammation of the internal pouch created after colon removal surgery. Researchers will give either etrasimod or a placebo to 40 high-risk patients for 48 weeks and track how many develop pouchitis. The …

This study tests a new treatment called EXE-346, which is a mix of 8 types of good bacteria. It aims to reduce how often people with an ileal pouch (a surgically created internal reservoir) need to have bowel movements. The trial will enroll 50 adults and first check safety, then…