Posttransplant acute limbic encephalitis
MONDO:0015595Posttransplant acute limbic encephalitis is a rare, acquired, non-paraneoplastic limbic encephalitis disorder, that develops in the setting of treatment-related immunosuppression, typically after allogeneic hemapoietic stem cell transplantation, characterized by onset of confusion, headache, anterograde amnesia, seizures and/or loss of consciousness 2-6 weeks following transplantation. Bilateral, non-enhancing T2 hyperintensities in limbic structures are observed on magnetic resonance imaging. Mild cerebrospinal fluid pleocytosis and syndrome of inappropriate antidiuretic hormone secretion may also be associated.
Also known as: PALE, pale
5 clinical trials for this condition and its sub-types, 0 tagged with Posttransplant acute limbic encephalitis itself.
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New cell prep method aims to tame transplant complications in kids
Disease control Expanded accessThis study offers a special way to prepare donor stem cells for children and teens under 22 who need a transplant but lack a perfectly matched sibling donor. The method uses the CliniMACS® system to remove certain immune cells, which may help reduce the risk of graft-versus-host …
Sponsor: Victor Aquino • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Rapid brain infection test could slash unnecessary antibiotic use
Diagnosis Recruiting nowThis study looks at whether a quick diagnostic test (BioFire FilmArray) can accurately predict the cause of meningitis or encephalitis in 182 adults. Participants with symptoms like fever, headache, or confusion will have their spinal fluid tested. The goal is to see if the test …
Sponsor: Federal University of Health Science of Porto Alegre • Aim: Diagnosis
Last updated Aug 23, 2026 00:00 UTC
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Nerve check may predict transplant complication risk
Knowledge-focused Recruiting nowThis study looks at 60 people getting a stem cell transplant to see if their autonomic nervous system (which controls things like heart rate and sweating) can help predict a serious complication called graft-versus-host disease (GvHD). Participants will have simple nerve tests be…
Sponsor: Institute of Hematology & Blood Diseases Hospital, China • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC