Polyneuropathy associated with IgM monoclonal gammapathy with anti-MAG

MONDO:0018977

Polyneuropathy associated with IgM monoclonal gammapathy (MG) with anti-MAG (myelin-associated-glycoprotein) activity is a demyelinating polyneuropathy characterized clinically by sensory ataxia, tremor, paresthesia, and impaired gait.

Also known as: anti-MAG neuropathy, neuropathy associated with monoclonal IgM antibodies to myelin-associated glycoprotein

13 clinical trials for this condition and its sub-types, 8 tagged with Polyneuropathy associated with IgM monoclonal gammapathy with anti-MAG itself.

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Where it sits in the disease tree

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Part of

↑ Acquired peripheral neuropathy (95)

Including sub-types (13) Tagged with Polyneuropathy associated with IgM monoclonal gammapathy with anti-MAG (8)

Trials to join now! 7 Not yet recruiting 1 Not yet finished but already full! 2 Completed 2 Terminated 1

Nerve signal test may forecast treatment success in rare nerve disease

Diagnosis Not yet recruiting

Anti-MAG neuropathy is a rare nerve condition that can cause disability, and treatments like rituximab or IVIg work differently for each person. Researchers are studying whether a simple nerve test, the Terminal Latency Index (TLI), can predict who will respond well to treatment.…

Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Diagnosis

Last updated Sep 02, 2026 00:00 UTC

Polyneuropathy associated with IgM monoclonal gammapathy with anti-MAG

Where it sits in the disease tree

Nerve signal test may forecast treatment success in rare nerve disease