POEMS syndrome
MONDO:0017364POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels.
Also known as: Crow-Fukase syndrome, PEP syndrome, POEMS syndrome, Takatsuki syndrome, osteosclerotic myeloma, polyneuropathy-endocrinopathy-plasma cell dyscrasia syndrome, polyneuropathy organomegaly, polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes syndrome
13 clinical trials for this condition and its sub-types, 8 tagged with POEMS syndrome itself.
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New drug cocktail aims to tame rare nerve and blood disorder
Disease control Recruiting nowThis phase 2 trial tests a combination of three drugs—carfilzomib, cyclophosphamide, and dexamethasone—in 20 people newly diagnosed with POEMS syndrome, a rare disorder affecting nerves and blood. The goal is to see if the regimen can reduce abnormal proteins and improve symptoms…
Phase 2 • Sponsor: Shanghai Changzheng Hospital • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Banking blood and bone marrow to decode plasma cell disorders
Knowledge-focused Recruiting nowResearchers at Peking University First Hospital are building a prospective cohort of 2,000 people with plasma cell disorders, including multiple myeloma, amyloidosis, and related conditions. Participants give blood, bone marrow, and urine samples before and after treatment, and t…
Sponsor: Peking University First Hospital • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Scientists hunt for genetic clues behind rare blood disorders
Knowledge-focused Recruiting nowThis study looks at a specific gene (IGLV1-44) to understand why it causes two different diseases: AL amyloidosis and POEMS syndrome. Researchers will analyze blood and bone marrow samples from 100 adults with these conditions or multiple myeloma. The goal is to find genetic patt…
Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Mayo clinic launches gut bacteria study for rare plasma cell disorders
Knowledge-focused Recruiting nowThis study looks at the gut microbiome (the bacteria living in the digestive system) of people with POEMS syndrome, multiple myeloma, MGUS, AL amyloidosis, and healthy household members. Participants provide stool samples at home using a collection kit. The goal is to understand …
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC
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New registry aims to unlock secrets of rare blood disorders
Knowledge-focused Recruiting nowThis study creates a registry for adults with plasma cell disorders, such as multiple myeloma and amyloidosis. Researchers will collect health information and optional blood samples to better understand these conditions. The goal is to gather data that could support future resear…
Sponsor: UNC Lineberger Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC