Pilocytic astrocytoma
MONDO:0016691Pilocytic astrocytoma is a rare subtype of low-grade glioma of the central nervous system characterized by a well circumscribed, often cystic, brain tumor with a discrete mural nodule and long, hair-like projections that extend from the neoplastic astrocytes. Depending on the primary localization and the size of the tumor, patients can present with signs of raised intracranial pressure (headache, vomiting, papilledema), blurred vision, decreased visual acuity, ataxia and/or nystagmus, among others. It is most commonly located in the cerebellum, but occurrence in the hypothalamus, brain stem, optic chiasma, and hemispheres has also been reported.
Also known as: astrocytoma, benign, astrocytoma, pilocytic, benign, grade I astrocytic neoplasm, grade I astrocytic tumor, grade I astrocytic tumour, grade I astrocytoma, pilocytic astrocytoma
1459 clinical trials for this condition and its sub-types, 12 tagged with Pilocytic astrocytoma itself.
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Sub-types of Pilocytic astrocytoma
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Pilomyxoid astrocytoma 5 trials
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Childhood pilocytic astrocytoma 1 trial
1 sub-type
- Juvenile pilocytic astrocytoma 0 trials
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Cerebellar pilocytic astrocytoma 0 trials
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New proton therapy aims to shield memory in kids with brain cancer
Disease control OngoingThis study tests a new way to give proton radiation to children with low-grade glioma, a common brain tumor. The goal is to avoid the hippocampus, a brain area key for memory, to reduce long-term memory loss. About 74 children will receive this targeted radiation, and researchers…
Sponsor: St. Jude Children's Research Hospital • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC
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Kids' brain tumor drugs tested for Long-Term safety
Disease control OngoingThis study follows 165 children who previously took dabrafenib and/or trametinib for certain brain tumors. Researchers want to see if these drugs are safe over the long term and how they affect growth. The children continue their treatment and are monitored for side effects and d…
Phase 4 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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Could a parasite drug fight childhood brain tumors?
Disease control OngoingThis trial is testing whether mebendazole, a drug commonly used to treat intestinal parasites, can help children with brain tumors called gliomas. The study combines mebendazole with standard chemotherapy drugs to see if it is safe and effective. It includes children and young ad…
Phase 1/2 • Sponsor: Julie Krystal • Aim: Disease control
Last updated Aug 08, 2026 00:03 UTC
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New hope for kids with tough brain tumors: targeted drug shows promise
Disease control OngoingThis study tests a drug called selumetinib in children and young adults with low grade glioma that has come back or not responded to other treatments. The drug works by blocking certain enzymes that help tumor cells grow. The goal is to find the best dose and see if it can shrink…
Phase 1/2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Can a common antifungal drug help fight brain cancer? new study investigates
Knowledge-focused OngoingThis early-phase trial is testing whether ketoconazole, a drug normally used for fungal infections, can get into brain tumors (gliomas) in enough amounts to possibly slow their growth. About 80 adults with different grades of glioma will take low doses of the drug before their sc…
Early phase 1 • Sponsor: Universitas Padjadjaran • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:34 UTC