Persistent polyclonal B-cell lymphocytosis

MONDO:0011672

Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare, generally benign, lymphoproliferative hematological disease characterized by: chronic, stable, persistent, polyclonal lymphocytosis of memory B-cell origin, the presence of binucleated lymphocytes in the peripheral blood, and a polyclonal increase in serum immunoglobulin M (IgM). Patients are most frequently asymptomatic or may present with mild splenomegaly.

Also known as: PPBL, persistent polyclonal B-cell lymphocytosis, persistent polyclonal B-cell lymphocytosis with binucleated lymphocytes

1575 clinical trials for this condition and its sub-types, 5 tagged with Persistent polyclonal B-cell lymphocytosis itself.

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Where it sits in the disease tree

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↑ Lymphoid hemopathy (4275)

Including sub-types (1575) Tagged with Persistent polyclonal B-cell lymphocytosis (5)

Trials to join now! 3 Completed 1 Terminated 1

Farmers' pesticide use linked to blood cancer precursors

Knowledge-focused Completed

This study looked at nearly 1,900 male farmers over age 50 to see if pesticide exposure is linked to early signs of blood cancers like multiple myeloma. Researchers collected blood and urine samples and compared those with and without exposure to the pesticide diazinon. No treatm…

Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused

Last updated Aug 30, 2026 00:00 UTC

Persistent polyclonal B-cell lymphocytosis

Where it sits in the disease tree

Farmers' pesticide use linked to blood cancer precursors