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Farmers' pesticide use linked to blood cancer precursors

NCT ID NCT01139476

Knowledge-focused Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 28, 2026 · Updated 7 times

Summary

This study looked at nearly 1,900 male farmers over age 50 to see if pesticide exposure is linked to early signs of blood cancers like multiple myeloma. Researchers collected blood and urine samples and compared those with and without exposure to the pesticide diazinon. No treatment was given; the goal was to gather information for future prevention research.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could help identify which pesticides raise the risk of blood cancers, pointing toward prevention strategies.
What could go wrong
This is an observational study, not a treatment trial. It cannot prove cause and effect, only associations. Results may not apply to women or younger people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

1,892 people

The number who actually took part.

Start date

Jun 2010

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Male pesticide applicators who are over 50 years of age, cancer-free, and participating in the Agricultural Health Study. Plus, a small control group comprising individuals who have not worked in agriculture or been occupationally exposed to pesticides.

Ages

18 to 100 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: Selected participants in the Agricultural Health Study are invited to participate in this aspect of the study. 1. Male private pesticide applicator; 2. Alive as of the latest update of the National Death Index G\\fDD and over 50 years of age at the time of initial contact: 3. Cancer free as of the most recent linkage with the appropriateCancer Registry; 4. Completed phase I, II and III interviews (these study subjects have the most comprehensive exposure evaluation and also will be the most interested in the study). EXCLUSION CRITERIA: 1. Deceased or no longer residing in Iowa or North Carolina; 2. Ever diagnosed with any type of cancer other than non-melanoma skin cancer; 3. Unable to speak English; 4. Have a blood clotting disorder such as hemophilia; or 5. Registered with the AHS as a "no contact".

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Conditions

The condition(s) this trial relates to.

leukemia monoclonal gammopathy of uncertain significance persistent polyclonal B-cell lymphocytosis plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Leukemia MGUS Monoclonal B-cell lymphocytosis Multiple myeloma

Contacts and locations

Locations

  • University of Iowa

    Iowa City, Iowa, 52242, United States

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