Persistent polyclonal B-cell lymphocytosis
MONDO:0011672Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare, generally benign, lymphoproliferative hematological disease characterized by: chronic, stable, persistent, polyclonal lymphocytosis of memory B-cell origin, the presence of binucleated lymphocytes in the peripheral blood, and a polyclonal increase in serum immunoglobulin M (IgM). Patients are most frequently asymptomatic or may present with mild splenomegaly.
Also known as: PPBL, persistent polyclonal B-cell lymphocytosis, persistent polyclonal B-cell lymphocytosis with binucleated lymphocytes
1575 clinical trials for this condition and its sub-types, 5 tagged with Persistent polyclonal B-cell lymphocytosis itself.
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Scientists watch and learn: no treatment, just tracking blood cancers over time
Knowledge-focused Recruiting nowThis study follows up to 1,000 adults with certain slow-growing blood cancers (CLL, SLL, LPL, WM) to track how the diseases change over time. Participants have regular check-ups and blood draws every 6 to 24 months, and may also have optional biopsies or scans for research. No tr…
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Sep 17, 2026 00:00 UTC
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Mayo clinic launches study to uncover hidden bone marrow weakness in blood cancer patients
Knowledge-focused Recruiting nowThis study looks at how chronic lymphocytic leukemia (CLL) and its early stage, monoclonal B-cell lymphocytosis (MBL), affect the bone marrow's ability to fight infections. Researchers will compare bone marrow samples from 50 participants—including people with CLL, people with MB…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Can your genes raise your risk for blood cancer? a new study aims to find out
Knowledge-focused Recruiting nowThis study looks at families where at least two living blood relatives have a blood cancer like lymphoma, leukemia, or multiple myeloma. Researchers want to understand how genetics and environmental factors contribute to these cancers. The goal is to identify inherited risks that…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC