Patent foramen ovale
MONDO:0020439A persistent opening in the atrial septum after birth. While a normal part of fetal circulation, the foramen ovale should close once the newborn begins breathing and the pressure in the left atrium exceeds that of the right atrium. While a PFO is generally asymptomatic, it can lead to the passage of clots from the venous circulation into the artierial circulation, resulting in paradoxical emboli, and possible strokes.
Also known as: ostium secundum type atrial septal defect, patent foramen ovale, patent foramen ovale (disease)
109 clinical trials for this condition and its sub-types, 36 tagged with Patent foramen ovale itself.
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New heart device aims to prevent strokes in patients with a hole in the heart
Disease control OngoingThis study tests a new device called the Occlutech Flex II PFO Occluder, which is used to close a small hole in the heart (PFO) that can cause strokes. The trial involves 450 people who have had a stroke with no clear cause and a PFO. Researchers want to see if the new device wor…
Sponsor: Occlutech International AB • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Heart device aims to cut stroke risk in PFO patients
Disease control OngoingThis study looks at a device called the AMPLATZER PFO Occluder, which is implanted to close a hole in the heart (PFO) in people who have had a stroke. Over 1,200 participants are being followed for up to 5 years to see if the device prevents another stroke and is safe. The goal i…
Sponsor: Abbott Medical Devices • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Heart-Device study aims to stop strokes in patients with a hole in the heart
Disease control OngoingThis study is checking how well a device called the GORE® CARDIOFORM Septal Occluder works and how safe it is for people who have had a stroke caused by a hole in the heart (PFO). Researchers will follow 300 patients in Japan for 12 months after the device is implanted. The goal …
Sponsor: W.L.Gore & Associates • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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Can a common heart drug stop rhythm problems after a Stroke-Related heart repair?
Prevention OngoingResearchers test whether flecainide, an antiarrhythmic drug, can prevent atrial arrhythmias in adults who have a patent foramen ovale (PFO) closed after a cryptogenic stroke. Participants receive flecainide or standard care for 3 to 6 months. An insertable cardiac monitor records…
Phase 3 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Prevention
Last updated Sep 11, 2026 00:00 UTC
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Heart hole or stroke trigger? global registry tracks who gets closure and what happens next
Knowledge-focused OngoingResearchers are running an international registry to follow adults who had an ischemic stroke or transient ischemic attack and also have a patent foramen ovale, a small opening between the upper chambers of the heart. The registry collects real-world information on how these pati…
Sponsor: Luciano A. Sposato • Aim: Knowledge-focused
Last updated Sep 20, 2026 00:00 UTC