Patent foramen ovale
MONDO:0020439A persistent opening in the atrial septum after birth. While a normal part of fetal circulation, the foramen ovale should close once the newborn begins breathing and the pressure in the left atrium exceeds that of the right atrium. While a PFO is generally asymptomatic, it can lead to the passage of clots from the venous circulation into the artierial circulation, resulting in paradoxical emboli, and possible strokes.
Also known as: ostium secundum type atrial septal defect, patent foramen ovale, patent foramen ovale (disease)
111 clinical trials for this condition and its sub-types, 36 tagged with Patent foramen ovale itself.
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Can a checklist and heart monitor stop repeat strokes?
Disease control Not yet recruitingResearchers are testing whether an educational and implementation tool helps hospitals follow best-practice guidelines for preventing second strokes caused by heart conditions. The trial enrolls about 2,400 patients who have had an ischemic stroke or a transient ischemic attack. …
Sponsor: Luciano A. Sposato • Aim: Disease control
Last updated Sep 20, 2026 00:00 UTC
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Can a diabetes pill help the heart heal after a hole is closed?
Disease control Not yet recruitingAdults with a secundum atrial septal defect (a hole in the heart) who are scheduled for device closure receive either dapagliflozin or a placebo for six months. Researchers use advanced echocardiography to measure how well the right side of the heart recovers and reverses its enl…
Sponsor: Assiut University • Aim: Disease control
Last updated Sep 19, 2026 00:00 UTC
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Can a stitch in time prevent a stroke? new device aims to close heart holes
Disease control Not yet recruitingThis trial tests a new suture system designed to close a patent foramen ovale (PFO), a small hole in the heart that can increase stroke risk. Researchers will compare the new device to an existing occluder in about 244 adults aged 18 to 65 with moderate-to-large PFOs. The goal is…
Sponsor: Shenzhen Bihe Medical Co., Ltd • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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New device aims to seal heart hole and prevent second strokes
Disease control Not yet recruitingThis study compares two medical devices used to close a small hole in the heart called a PFO, which can cause strokes. About 1,260 adults who have had a stroke or mini-stroke in the past year will be randomly assigned to receive either the Cocoon PFO Occluder or the Amplatzer PFO…
Sponsor: Giuseppe Tarantini • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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New dissolving heart plug could stop strokes without lifelong drugs
Disease control Not yet recruitingThis study tests a new biodegradable device that closes a common heart hole (PFO) in people who have already had a stroke or mini-stroke. The device is placed through a tube in the leg and dissolves over time, leaving no permanent implant. The trial will check if it safely and ef…
Sponsor: Shanghai Lingsi Medical Technology Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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Heart procedure may offer lasting migraine relief, new study hopes to prove
Symptom relief Not yet recruitingThis study looks at people with migraines who also have a small hole in the heart (PFO). Participants first take a blood-thinning drug (prasugrel) to see if their migraines improve. Those who respond are randomly assigned to either continue the drug alone or have a procedure to c…
Phase 3 • Sponsor: Columbia University • Aim: Symptom relief
Last updated Jul 31, 2026 00:00 UTC
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New heart camera aims to make procedures safer
Knowledge-focused Not yet recruitingThis study will test a new ultrasound catheter called VeriSight Pro that takes pictures from inside the heart. Doctors will use it during procedures like closing a hole in the heart or fixing a valve. The goal is to see if it helps guide these procedures safely and effectively. A…
Sponsor: Philips Clinical & Medical Affairs Global • Aim: Knowledge-focused
Last updated Aug 21, 2026 00:00 UTC
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Could a tiny heart hole worsen altitude sickness?
Knowledge-focused Not yet recruitingThis study looks at how a small opening in the heart, called a patent foramen ovale (PFO), affects blood flow and oxygen levels during exercise and simulated high altitude. About a third of people have this opening, which may allow oxygen-poor blood to mix with oxygen-rich blood,…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Aug 05, 2026 00:00 UTC
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Heart hole closure may rewire migraine brains, study hints
Knowledge-focused Not yet recruitingThis study looks at 45 adults with migraine and a small hole in the heart (PFO). Researchers will use brain scans and thinking tests to see if closing the hole changes brain activity, mood, and migraine symptoms over a year. The goal is to understand the link between PFO and migr…
Sponsor: Second Xiangya Hospital of Central South University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC