Paroxysmal cold hemoglobinuria

MONDO:0019533

Paroxysmal cold hemoglobinuria (PCH) is a very rare subtype of autoimmune hemolytic anemia (AIHA), caused by the presence of cold-reacting autoantibodies in the blood and characterized by the sudden presence of hemoglobinuria, typically after exposure to cold temperatures.

Also known as: Donath-Landsteiner hemolytic anaemia, Donath-Landsteiner hemolytic anemia, Donath-Landsteiner syndrome, PCH, hemoglobinuria paroxysmal cold

44 clinical trials for this condition and its sub-types, 0 tagged with Paroxysmal cold hemoglobinuria itself.

Follow this condition to get notified about new trials

Where it sits in the disease tree

Browse by category →

Part of

↑ Autoimmune hemolytic anemia, cold type (15)

Including sub-types (44) Tagged with Paroxysmal cold hemoglobinuria (0)

Trials to join now! 16 Not yet recruiting 11 Not yet finished but already full! 6 Completed 10 Terminated 1

Biopsy tolerance study ends early – what we know

Knowledge-focused Stopped early

This study aimed to understand how well patients tolerate biopsies for autoimmune diseases and whether they feel properly informed. It planned to enroll 505 people but was terminated early. The results may help improve patient experience with these common procedures.

Sponsor: University Hospital, Brest • Aim: Knowledge-focused

Last updated Jun 28, 2026 00:00 UTC

Paroxysmal cold hemoglobinuria

Where it sits in the disease tree

Biopsy tolerance study ends early – what we know