Paraganglioma
MONDO:0000448A benign or malignant neoplasm arising from paraganglia located along the sympathetic or parasympathetic nerves. Infrequently, it may arise outside the usual distribution of the sympathetic and parasympathetic paraganglia. Tumors arising from the adrenal gland medulla are called pheochromocytomas. Morphologically, paragangliomas usually display a nesting (Zellballen) growth pattern. There are no reliable morphologic criteria to distinguish between benign and malignant paragangliomas. The only definitive indicator of malignancy is the presence of regional or distant metastases.
Also known as: Paraganglionic neoplasm, Paraganglionic tumor, Paraganglionic tumour, neoplasm of paraganglion, neoplasm of the paraganglion, paraganglioma, paragangliomas, paraganglion neoplasm
1516 clinical trials for this condition and its sub-types, 53 tagged with Paraganglioma itself.
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Sub-types of Paraganglioma
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Sympathetic paraganglioma 0 trials · 16 incl. sub-types
2 sub-types
- Adrenal gland pheochromocytoma 5 trials · 16 incl. sub-types Sub-types →
- Extra-adrenal sympathetic paraganglioma 0 trials
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Head and neck paraganglioma 1 trial
4 sub-types
- Carotid body paraganglioma 0 trials Sub-types →
- Jugulotympanic paraganglioma 0 trials Sub-types →
- Tympanic paraganglioma 0 trials
- Vagus nerve paraganglioma 0 trials
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Non-secreting paraganglioma 0 trials
1 sub-type
- Non-secreting chemodectoma 0 trials
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Parasympathetic paraganglioma 0 trials
4 sub-types
- Carotid body paraganglioma 0 trials Sub-types →
- Jugulotympanic paraganglioma 0 trials Sub-types →
- Neoplasm of aortic body 0 trials
- Vagus nerve paraganglioma 0 trials
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3 sub-types
- Multiple paragangliomas associated with polycythemia 0 trials
- Sporadic pheochromocytoma 0 trials
- Sporadic secreting paraganglioma 0 trials
Most studied deeper sub-types
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New blood test could spot hidden tumors causing high blood pressure
Diagnosis CompletedThis study looked at whether a new blood marker called EM66 can help doctors tell the difference between high blood pressure caused by rare adrenal tumors (pheochromocytoma or paraganglioma) and regular high blood pressure. Researchers measured EM66 levels in 60 adults with eithe…
Sponsor: University Hospital, Rouen • Aim: Diagnosis
Last updated Jun 27, 2026 09:02 UTC
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Could a smartphone replace clinic visits for rare tumor survivors?
Knowledge-focused CompletedThis study tests whether a remote monitoring program can reliably track the health of people who have had surgery for pheochromocytoma or paraganglioma (PPGL), rare adrenal tumors. Participants use an internet platform to report their data, which is compared to information collec…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jul 10, 2026 00:00 UTC
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Doctors create new tool to predict surgery difficulty for rare tumors
Knowledge-focused CompletedThis study created a new imaging-based grading system to help doctors predict how complex and risky surgery will be for patients with rare adrenal and nerve tumors called PPGL. Researchers used 3D scans from 500 patients to develop the system, aiming to improve surgical planning …
Sponsor: Peking University First Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC