New blood test could spot hidden tumors causing high blood pressure

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Patients with pheochromocytoma/paraganglioma Inclusion criteria : * men \& women, age \> 18 years old * Newly diagnosed patient : suspicion of pheochromocytoma or paraganglioma with elevation of urinary metanephrines and/or normetanephrines along with evidence of tumor which surgical removal is considered (histological findings following surgery will be the gold standard for final diagnosis and inclusion in the study) * During follow-up of a patient with known genetic predisposition to pheochromocytoma/paraganglioma : suspicion of pheochromocytoma or paraganglioma with or without elevation of urinary metanephrines and/or normetanephrines along with evidence of a tumor which surgical removal is considered (histological findings following surgery will be the gold standard for final diagnosis and inclusion in the study) , * Patients with known pheochromocytoma/paraganglioma, whether malignant or not, whether with metanephrine secretion or not, With tumor sites at inclusion in the study * Patients informed and willing to participate in the study * Patients with medical insurance (French social security) Non inclusion criteria * Patients newly diagnosed, recently operated and the histological findings disprove pheochromocytoma or paraganglioma. * patient imprisoned or under legal protection. Patients with essential hypertension Inclusion criteria * men \& women, age \> 18 years old * paired with a patient with pheochromocytoma/paraganglioma for : gender, age (± 5 years) and centre * patient with hypertension. No aetiology was found after initial check up. * Normal 24 hours urinary excretion of metanephrines \& normetanephrines * For women of childbearing potential : effective contraceptive method and negative urinary pregnancy test * Patients informed and willing to participate in the study * Patients with medical insurance (French social security) Non inclusion criteria * Treatment with proton-pump inhibitors in the 8 days before inclusion in the study * Treatment with beta-blockers, antidepressants, Benzodiazepins, dopa, alphamethyl dopa, if this treatment cannot be interrupted during the study (i.e. for approximately 10 days) * patient imprisoned or under legal protection.