Papillon-Lefevre disease

MONDO:0009490

Papillon-Lefevre syndrome (PLS) is a rare ectodermal dysplasia characterized by palmoplantar keratoderma associated with early-onset periodontitis.

Also known as: PLS, Papillon Lefèvre Syndrome, keratosis palmoplantar-periodontopathy syndrome, Keratoris palmoplantaris with periodontopathia, PALS, PAPILLON-Lefevre syndrome, Papillon-LEFèvre syndrome, Pls

26 clinical trials for this condition and its sub-types, 5 tagged with Papillon-Lefevre disease itself.

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Where it sits in the disease tree

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↑ Autosomal recessive disease (999) ↑ Periodontal disorder (982) ↑ Disorder of lysosomal-related organelles (17) ↑ Functional neutrophil defect (13) ↑ Diffuse palmoplantar keratoderma (12) ↑ CTSC-related disorder (11)

Including sub-types (26) Tagged with Papillon-Lefevre disease (5)

Trials to join now! 2 Not yet finished but already full! 2 Completed 1

Wearable sensors monitor ALS progression in new study

Knowledge-focused Completed

This study tests whether wearable sensors and digital home tasks can track changes in movement, speech, and falls in people with ALS. About 20 participants will wear neck and wrist sensors and complete speech and handwriting tests over 48 weeks. The goal is to see if these digita…

Sponsor: Milton S. Hershey Medical Center • Aim: Knowledge-focused

Last updated Jul 01, 2026 00:00 UTC

Papillon-Lefevre disease

Where it sits in the disease tree

Wearable sensors monitor ALS progression in new study