Pancreatic insulinoma

This study tests a new medicine called ersodetug for people whose tumors cause dangerously low blood sugar that standard treatments can't control. About 16 adults with insulin-producing tumors will receive the drug alongside their usual care. The main goal is to see if ersodetug …

This study is testing a procedure called EUS-guided radiofrequency ablation (EUS-RFA) for people with pancreatic insulinoma, a rare tumor that causes low blood sugar. The procedure uses a thin needle passed through an endoscope to deliver heat and destroy the tumor. Researchers w…

This study is testing a procedure called EUS-RFA, which uses a thin needle guided by ultrasound to heat and destroy small tumors in the pancreas or adrenal glands. About 138 participants will receive this treatment as part of their standard care and be followed for up to 5 years.…

This program provides an investigational drug, ersodetug, to people with dangerously low blood sugar caused by certain tumors. It is for those who cannot join a formal clinical trial. The goal is to help control blood sugar levels when standard treatments are not enough.

Researchers are testing a new PET/CT imaging tracer designed to spot insulinomas, rare pancreatic tumors that cause dangerously low blood sugar. These tumors are often tiny and easy to miss on standard CT, ultrasound, or PET scans. The tracer targets a protein called GLP-1R that …

This trial tests whether a single injection of a radioactive tracer called 68Ga/18F-Exendin 4 can improve PET/CT scans for finding tumors that carry GLP-1 receptors. Researchers will enroll 500 adults with suspected or known tumors, including insulinomas, and measure how brightly…

This study offers expanded access to a PET scan using a radioactive tracer called 18F-DOPA to locate small, insulin-producing lesions in the pancreas. It is for patients with congenital hyperinsulinism, Beckwith-Wiedemann syndrome, or insulinoma who have low blood sugar. The goal…

This study is testing whether a special PET/MRI scan using 18F-DOPA can accurately locate small, overactive areas in the pancreas that cause too much insulin (hyperinsulinism). The goal is to help doctors decide if surgery can remove just the problem spot, potentially curing the …

This study aims to better understand why some people experience dangerously low blood sugar (hypoglycemia), especially after fasting. Researchers will admit 1,500 adults to the NIH Clinical Center for controlled fasting and a series of blood tests to measure insulin and other fac…