Pachyonychia congenita

MONDO:0016471

Pachyonychia congenita (PC) is a rare genodermatosis predominantly featuring painful palmoplantar keratoderma, thickened nails, cysts and whitish oral mucosa.

Also known as: PC, pachyonychia congenita type 1, congenital pachyonychia, pachyonychia congenita syndrome

1 clinical trial for this condition and its sub-types, 1 tagged with Pachyonychia congenita itself.

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Where it sits in the disease tree

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Part of

↑ Focal palmoplantar keratoderma (1)

Sub-types of Pachyonychia congenita

Including sub-types (1) Tagged with Pachyonychia congenita (1)

Not yet recruiting 1

Could a cancer pill ease rare, painful skin diseases?

Disease control Not yet recruiting

This early-phase trial tests whether low doses of erlotinib, a drug originally used for cancer, can improve symptoms of rare genetic skin conditions called keratinopathies. About 44 adults with confirmed diagnoses will take increasing doses over 24 weeks. The goal is to see if it…

Phase 1/2 • Sponsor: Northwestern University • Aim: Disease control

Last updated Aug 05, 2026 00:00 UTC

Pachyonychia congenita

Where it sits in the disease tree

Could a cancer pill ease rare, painful skin diseases?