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Osteogenesis imperfecta
MONDO:0019019Osteogenesis imperfecta (OI) comprises a heterogeneous group of genetic disorders characterized by increased bone fragility, low bone mass, and susceptibility to bone fractures with variable severity.
Also known as: Lobstein disease, OI, Osteopsathyrosis, Porak and Durante disease, brittle bone disease, glass bone disease, Vrolik disease
329 clinical trials for this condition and its sub-types, 35 tagged with Osteogenesis imperfecta itself.
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Sub-types of Osteogenesis imperfecta
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Osteogenesis imperfecta and a reduction of bone mineral density. 0 trials · 307 incl. sub-types
34 sub-types
- Osteoporosis 277 trials · 295 incl. sub-types Sub-types →
- Osteogenesis imperfecta type 3 9 trials
- Osteogenesis imperfecta type 1 8 trials Sub-types →
- Osteogenesis imperfecta type 4 7 trials
- Osteogenesis imperfecta type 5 1 trial
- Bruck syndrome 2 0 trials
- Cole-Carpenter syndrome 1 0 trials
- Cole-Carpenter syndrome 2 0 trials
- Ehlers-Danlos syndrome, spondylodysplastic type, 1 0 trials
- Singleton-Merten syndrome 1 0 trials
- Singleton-Merten syndrome 2 0 trials
- Wiedemann-Rautenstrauch syndrome 0 trials
- Autosomal recessive cutis laxa type 2A 0 trials Sub-types →
- Autosomal recessive cutis laxa type 2B 0 trials
- Calvarial doughnut lesions-bone fragility syndrome 0 trials
- Geroderma osteodysplastica 0 trials
- Gnathodiaphyseal dysplasia 0 trials
- Osteogenesis imperfecta type 10 0 trials
- Osteogenesis imperfecta type 11 0 trials
- Osteogenesis imperfecta type 12 0 trials
- Osteogenesis imperfecta type 14 0 trials
- Osteogenesis imperfecta type 15 0 trials
- Osteogenesis imperfecta type 16 0 trials
- Osteogenesis imperfecta type 17 0 trials
- Osteogenesis imperfecta type 2 0 trials
- Osteogenesis imperfecta type 6 0 trials
- Osteogenesis imperfecta type 7 0 trials
- Osteogenesis imperfecta type 8 0 trials
- Osteogenesis imperfecta type 9 0 trials
- Osteogenesis imperfecta, type 18 0 trials
- Osteogenesis imperfecta, type 19 0 trials
- Osteoporosis-pseudoglioma syndrome 0 trials
- Short stature-optic atrophy-Pelger-Huët anomaly syndrome 0 trials
- Spondylo-ocular syndrome 0 trials
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Brittle bone disorder 4 trials
1 sub-type
- Brittle bone syndrome lethal type 0 trials
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Osteogenesis imperfecta type 13 0 trials
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Osteogenesis imperfecta, IIA 22 0 trials
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Osteogenesis imperfecta, type 20 0 trials
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Osteogenesis imperfecta, type 21 0 trials
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Osteogenesis imperfecta, type 23 0 trials
Most studied deeper sub-types
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A common supplement may shield bones in kidney disease — a trial puts it to the test
Disease control Stopped earlyThis pilot trial investigates whether potassium citrate can improve bone quality and strength in adults and children with chronic kidney disease. Participants take either potassium citrate or a placebo for six months, along with blood and urine tests and advanced bone scans. The …
Phase 2/3 • Sponsor: Albert Einstein College of Medicine • Aim: Disease control
Last updated Jul 30, 2026 00:00 UTC
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Could a common cholesterol drug protect bones and hearts after spinal injury?
Disease control Stopped earlyThis study tested whether the statin drug rosuvastatin, taken daily with supplements, could improve bone density and reduce heart disease risk in adults with long-term spinal cord injury. Only 8 people enrolled before the trial was stopped early. Participants received either rosu…
Phase 2 • Sponsor: Dr. B. Catharine. Craven • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC
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Experimental drug for brittle bones tested in small trial
Disease control Stopped earlyThis early-stage trial tested a single dose of a drug called SAR439459 in 16 adults with osteogenesis imperfecta (brittle bone disease). The drug aims to block a protein that may weaken bones. The study focused on safety and how the drug moves through the body, but it was termina…
Phase 1 • Sponsor: Sanofi • Aim: Disease control
Last updated Jun 26, 2026 16:39 UTC
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Elderly arthritis study reveals hidden health risks
Knowledge-focused Stopped earlyThis study aimed to understand how age influences serious health issues like infections, cancer, heart disease, and bone fractures in people with rheumatoid arthritis. Researchers compared patients over 65 with younger adults (18-50) who had the same disease. The study was stoppe…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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HIV drugs may weaken bones: new study investigates
Knowledge-focused Stopped earlyThis study looked at bone density in HIV-positive men to see if antiretroviral drugs cause bone thinning. Researchers compared men starting HIV treatment with those not yet on therapy over two years. The goal was to understand why bone loss is more common in HIV patients.
Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC