Oral cavity carcinoma
MONDO:0044925A carcinoma arising in the oral cavity. Most oral cavity carcinomas are squamous cell carcinomas of the tongue, buccal mucosa, or gums. Less frequent morphologic variants include mucoepidermoid carcinoma and adenocarcinoma.
Also known as: oral cavity cancer, carcinoma of mouth, carcinoma of oral cavity, carcinoma of the oral cavity, mouth carcinoma, oral cavity carcinoma
3147 clinical trials for this condition and its sub-types, 16 tagged with Oral cavity carcinoma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Oral cavity carcinoma
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Oral cavity squamous cell carcinoma 139 trials · 154 incl. sub-types
7 sub-types
- Tongue squamous cell carcinoma 9 trials · 13 incl. sub-types Sub-types →
- Salivary gland squamous cell carcinoma 4 trials Sub-types →
- Verrucous carcinoma of oral cavity 3 trials
- Squamous cell carcinoma of buccal mucosa 2 trials
- Squamous cell carcinoma of floor of mouth 2 trials
- Squamous cell carcinoma of lip 2 trials
- Maxillary sinus squamous cell carcinoma 1 trial
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Salivary gland carcinoma 26 trials · 36 incl. sub-types
13 sub-types
- Major salivary gland carcinoma 6 trials Sub-types →
- Salivary gland squamous cell carcinoma 4 trials Sub-types →
- Salivary duct carcinoma 3 trials
- Salivary gland adenoid cystic carcinoma 3 trials Sub-types →
- Mammary analog secretory carcinoma 0 trials
- Minor salivary gland carcinoma 0 trials Sub-types →
- Salivary gland basal cell adenocarcinoma 0 trials
- Salivary gland carcinoma ex pleomorphic adenoma 0 trials Sub-types →
- Salivary gland epithelial myoepithelial carcinoma 0 trials
- Salivary gland large cell carcinoma 0 trials
- Salivary gland mucinous adenocarcinoma 0 trials
- Salivary gland mucoepidermoid carcinoma 0 trials Sub-types →
- Salivary gland small cell carcinoma 0 trials
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Oral cavity carcinoma in situ 5 trials
1 sub-type
- Lip carcinoma in situ 0 trials
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Tongue carcinoma 4 trials
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Carcinoma of lip 0 trials · 2 incl. sub-types
2 sub-types
- Squamous cell carcinoma of lip 2 trials
- Lip carcinoma in situ 0 trials
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Carcinoma of hard palate 1 trial
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Carcinoma of soft palate 1 trial
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Intraoral basal cell carcinoma 0 trials
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Oral cavity mucoepidermoid carcinoma 0 trials
2 sub-types
Most studied deeper sub-types
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Five days of radiation instead of weeks: a new test for head and neck cancer
Disease control CancelledResearchers are testing a shorter radiation schedule for people with head and neck cancer who have had surgery. Standard radiation after surgery often takes several weeks, but this trial gives five treatments over five days. The study enrolls 50 adults with high-risk features, su…
Sponsor: All India Institute of Medical Sciences • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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Can heat make radiation more effective against head and neck cancer?
Disease control OngoingThis trial tests whether adding weekly thermotherapy, a treatment that heats the tumor and lymph nodes, to standard radiotherapy can help people with head and neck cancer who cannot receive chemotherapy. The goal is to find a safe dose of thermotherapy that does not cause severe …
Phase 1 • Sponsor: Erasmus Medical Center • Aim: Disease control
Last updated Sep 04, 2026 00:00 UTC
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New proton beam therapy aims to zap head and neck cancer with fewer side effects
Disease control OngoingThis study is testing whether a precise form of radiation called proton therapy can control head and neck cancer after surgery as well as standard X-ray radiation, but with fewer side effects. About 174 adults with newly diagnosed head and neck cancer will receive either proton t…
Phase 2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jul 18, 2026 00:00 UTC
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Immunotherapy duo takes on rare tumors
Disease control OngoingThis phase 2 trial is testing a combination of two immunotherapy drugs, nivolumab and ipilimumab, in 798 people with over 50 types of rare cancers. The goal is to see if these drugs can shrink tumors by helping the immune system attack cancer cells. Participants receive the drugs…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Could a common diabetes drug stop oral cancer before it starts?
Prevention OngoingThis phase 2 trial tests whether metformin, a widely used diabetes drug, can prevent oral cancer in 26 people with precancerous mouth lesions (leukoplakia or erythroplakia). Participants take metformin by mouth, and researchers check if the lesions shrink or disappear. The goal i…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Prevention
Last updated Jun 28, 2026 00:00 UTC
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HPV Vaccine's Long-Term effects under the microscope in costa rica
Knowledge-focused OngoingThis study follows over 8,600 women in Costa Rica who received the HPV vaccine (types 16 and 18) years ago, plus unvaccinated controls, to see how well the vaccine protects over time. Researchers are checking for cervical lesions, immune markers, and any increase in infections fr…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Aug 30, 2026 00:00 UTC