Onchocerciasis
MONDO:0017137Onchocerciasis is a form of filariasis, caused by the parasitic worm Onchocerca volvulus, transmitted by the black fly. The infection can either be asymptomatic or manifest as an ocular disease (river blindness) with itchy eyes, erythema, photophobia, onchodermatitis or onchocercal skin disease (classified into acute papular, chronic papular, lichenified, atrophic, and depigmentated) and onchocercomas (over bony prominences). Other classic clinical manifestations are ichthyosis-like lesions (''lizard skin'') and ''hanging groin'', which may be associated with lymphadenopathy.
Also known as: Onchocerca volvulus infection, infection by Onchocerca volvulus, onchocerciasis, River blindness, Robles' disease, infection caused by Onchocerca volvulus, onchocercosis
10 clinical trials for this condition and its sub-types, 9 tagged with Onchocerciasis itself.
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Browse by category →Sub-types of Onchocerciasis
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Ocular onchocerciasis 2 trials
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Twice-Yearly drug could beat river blindness
Disease control OngoingThis study tests if taking moxidectin twice a year is safer and more effective than once a year for treating river blindness, a parasitic disease. About 323 people in the Democratic Republic of Congo will receive either moxidectin or ivermectin annually or biannually. The goal is…
Phase 3 • Sponsor: Medicines Development for Global Health • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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New drug cocktails aim to beat river blindness
Disease control OngoingThis study tests four different drug combinations in 300 adults with onchocerciasis (river blindness), a parasitic disease. Participants first receive ivermectin to clear skin and eye parasites, then get one of the new combos. The goal is to see which combo is safest and most eff…
Phase 2 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC