Non-Langerhans cell histiocytosis
MONDO:0015531Group of disorders which feature accumulations of active HISTIOCYTES and LYMPHOCYTES, but where the histiocytes are not LANGERHANS CELLS. The group includes HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; SINUS HISTIOCYTOSIS; xanthogranuloma; reticulohistiocytoma; juvenile XANTHOGRANULOMA; xanthoma disseminatum; as well as the lipid storage diseases (SEA-BLUE HISTIOCYTE SYNDROME; and NIEMANN-PICK DISEASES).
Also known as: non-Langerhans-cell histiocytosis, histiocytosis, non-Langerhans-cell
44 clinical trials for this condition and its sub-types, 1 tagged with Non-Langerhans cell histiocytosis itself.
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Sub-types of Non-Langerhans cell histiocytosis
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Niemann-Pick disease 10 trials · 22 incl. sub-types
4 sub-types
- Niemann-Pick disease type C 12 trials · 13 incl. sub-types Sub-types →
- Acid sphingomyelinase deficiency 7 trials · 10 incl. sub-types Sub-types →
- Niemann-Pick disease type E 0 trials
- Chronic neurovisceral acid sphingomyelinase deficiency 0 trials
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Erdheim-Chester disease 14 trials
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1 sub-type
- H syndrome 0 trials
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Juvenile xanthogranuloma 4 trials
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Xanthogranuloma 1 trial
1 sub-type
- Adult xanthogranuloma 0 trials
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Benign cephalic histiocytosis 0 trials
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Generalized eruptive histiocytosis 0 trials
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Multicentric reticulohistiocytosis 0 trials
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Necrobiotic xanthogranuloma 0 trials
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Papular xanthoma 0 trials
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Progressive nodular histiocytosis 0 trials
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Sea-blue histiocyte syndrome 0 trials
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Xanthoma disseminatum 0 trials
Most studied deeper sub-types
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New cocktail of cancer drugs tested in desperate cases
Disease control Stopped earlyThis early-phase trial tested combinations of the drugs bevacizumab and temsirolimus, sometimes with valproic acid or cetuximab, in 154 people with advanced cancers or certain non-cancerous but progressive diseases. The main goal was to find safe doses and look for any signs that…
Phase 1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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Scientists dive into rare cholesterol disorders to uncover clues
Knowledge-focused Stopped earlyThis study looks at rare genetic disorders where the body can't make cholesterol properly, which can cause birth defects and learning problems. Researchers collect blood, urine, and tissue samples from affected people and their families to learn more about these conditions. The g…
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated Aug 14, 2026 00:00 UTC