Neurofibromatosis
MONDO:0021061A hereditary neoplastic syndrome in which tumors grow in the nervous system. There are typically 3 main types recognized, but other forms with uncertain etiology exist.
Also known as: Recklinghausen's neurofibromatosis, acoustic neurofibromatosis, central Neurofibromatosis, neurofibromatosis, neurofibromatosis syndrome, peripheral Neurofibromatosis, type IV neurofibromatosis of riccardi, von Reklinghausen disease
125 clinical trials for this condition and its sub-types, 19 tagged with Neurofibromatosis itself.
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Sub-types of Neurofibromatosis
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Neurofibromatosis type 1 73 trials
3 sub-types
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NF2-related schwannomatosis 21 trials
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Schwannomatosis 3 trials
4 sub-types
- 22q-related schwannomatosis 0 trials
- LZTR1-related schwannomatosis 0 trials
- SMARCB1-related schwannomatosis 0 trials
- Neurofibromatosis, type III, mixed central and peripheral 0 trials
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Neurofibromatosis-Noonan syndrome 2 trials
1 sub-type
- Watson syndrome 0 trials
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Teens with NF try video coaching to boost mood and health
Symptom relief CompletedThis study tested two 8-week stress management programs delivered via secure video calls for 196 adolescents aged 12–17 with neurofibromatosis (NF1 or NF2). The goal was to see if these programs could improve emotional, social, and physical quality of life. Both programs taught c…
Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 13:07 UTC
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Video-Based stress program aims to ease life with neurofibromatosis
Symptom relief CompletedThis study tested two stress and symptom management programs for adults with neurofibromatosis (NF1, NF2, or schwannomatosis). The programs were delivered through live videoconferencing over 8 weekly sessions. Researchers measured changes in quality of life and emotional well-bei…
Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 08:07 UTC
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Scientists track skin tumors in NF1 to uncover clues for future therapies
Knowledge-focused CompletedThis study followed 17 adults with neurofibromatosis type 1 (NF1) over two years to learn how their skin tumors (dermal neurofibromas) grow and change. Researchers used special cameras and skin biopsies to measure tumor growth and look for genes that might influence it. The goal …
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Can a simple guide boost lifesaving screenings for NF1 patients?
Knowledge-focused CompletedThis study aims to find out which of two educational programs better helps adults with Neurofibromatosis 1 (NF1) and parents of children with NF1 get the recommended health screenings during their regular checkups. Participants live across the U.S. and do not currently visit a sp…
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Aug 23, 2026 00:00 UTC
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New scan and genetic tests aim to catch cancer early in NF1 patients
Knowledge-focused CompletedThis study looked at people with neurofibromatosis type 1 (NF1) to better understand how harmless tumors (plexiform neurofibromas) turn into a rare cancer called MPNST. Ten participants had MRI, PET scans, and tumor biopsies. Researchers tested whether a special PET scan (FLT PET…
Phase 1 • Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Aug 06, 2026 00:00 UTC