Neuroaxonal dystrophy
MONDO:0002283A nonspecific term referring both to the pathologic finding of swelling of distal portions of axons in the brain and to disorders which feature this finding. Neuroaxonal dystrophy is seen in various genetic diseases, vitamin deficiencies, and aging. Infantile neuroaxonal dystrophy is an autosomal recessive disease characterized by arrested psychomotor development at 6 months to 2 years of age, ataxia, brain stem dysfunction, and quadriparesis. Juvenile and adult forms also occur. Pathologic findings include brain atrophy and widespread accumulation of axonal spheroids throughout the neuroaxis, peripheral nerves, and dental pulp. (From Davis & Robertson, Textbook of Neuropathology, 2nd ed, p927)
9 clinical trials for this condition and its sub-types, 1 tagged with Neuroaxonal dystrophy itself.
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Browse by category →Sub-types of Neuroaxonal dystrophy
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Neurodegeneration with brain iron accumulation 1 trial · 8 incl. sub-types
14 sub-types
- Neurodegeneration with brain iron accumulation 5 4 trials
- Pantothenate kinase-associated neurodegeneration 4 trials Sub-types →
- PLA2G6-associated neurodegeneration 1 trial Sub-types →
- Kufor-Rakeb syndrome 0 trials Sub-types →
- Woodhouse-Sakati syndrome 0 trials
- Aceruloplasminemia 0 trials
- Early-onset progressive encephalopathy-spastic ataxia-distal spinal muscular atrophy syndrome 0 trials
- Fatty acid hydroxylase-associated neurodegeneration 0 trials
- Neurodegeneration with brain iron accumulation 4 0 trials
- Neurodegeneration with brain iron accumulation 6 0 trials
- Neurodegeneration with brain iron accumulation 7 0 trials
- Neurodegeneration with brain iron accumulation 8 0 trials
- Neurodegeneration with brain iron accumulation 9 0 trials
- Neuroferritinopathy 0 trials
Most studied deeper sub-types
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Could a digital tool help sarcoma patients handle treatment side effects?
Symptom relief Recruiting nowThis study tests whether a digital personalized care plan (ePCP) can help people with advanced sarcoma who are on chemotherapy. About 377 participants will either get the digital plan plus standard care, or standard care alone. The main goal is to see if the digital tool reduces …
Sponsor: Centre Oscar Lambret • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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AI hunts for early clues to Parkinson's and Alzheimer's progression
Knowledge-focused Recruiting nowThis study follows 600 people with neurodegenerative diseases such as Parkinson's, Alzheimer's, and related conditions over 1 to 10 years. Researchers collect data from routine clinical exams, brain imaging, movement analysis, and blood tests. They use statistical tools and artif…
Sponsor: Casa di Cura San Raffaele Cassino • Aim: Knowledge-focused
Last updated Sep 04, 2026 00:00 UTC
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Major study tracks rare brain diseases to unlock their secrets
Knowledge-focused Recruiting nowThis study follows 1500 people with rare genetic brain disorders to learn how these diseases progress. Researchers measure thinking, movement, and daily living skills over time, and also look at brain scans and body fluids. The goal is to better understand the diseases and how tr…
Sponsor: University of Pittsburgh • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Massive leukodystrophy biobank aims to unlock disease secrets
Knowledge-focused Recruiting nowThis study collects medical information and biological samples (like blood or tissue) from up to 12,000 people with leukodystrophies—rare disorders that damage the brain's white matter. Researchers will use this data to find new genetic causes, develop biomarkers for future trial…
Sponsor: Children's Hospital of Philadelphia • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:55 UTC