Nephrotic syndrome
MONDO:0005377A collection of symptoms that include severe edema, proteinuria, and hypoalbuminemia; it is indicative of renal dysfunction.
Also known as: nephrotic syndrome, nephrotic syndromes, syndrome, nephrotic, syndromes, nephrotic, nephrosis
71 clinical trials for this condition and its sub-types, 47 tagged with Nephrotic syndrome itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Nephrotic syndrome
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Idiopathic nephrotic syndrome 13 trials · 24 incl. sub-types
5 sub-types
- Idiopathic multidrug-resistant nephrotic syndrome 6 trials
- Idiopathic steroid-sensitive nephrotic syndrome 4 trials Sub-types →
- Sporadic idiopathic steroid-resistant nephrotic syndrome 0 trials · 2 incl. sub-types Sub-types →
- Familial idiopathic steroid-resistant nephrotic syndrome 0 trials Sub-types →
- Idiopathic steroid-resistant nephrotic syndrome with sensitivity to second-line immunosuppressive therapy 0 trials
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Familial nephrotic syndrome 0 trials · 22 incl. sub-types
18 sub-types
- Immunoglobulin-mediated membranoproliferative glomerulonephritis 12 trials
- Idiopathic multidrug-resistant nephrotic syndrome 6 trials
- Nephrotic syndrome 14 3 trials
- Nephrotic syndrome, type 4 1 trial
- LAMB2-related infantile-onset nephrotic syndrome 0 trials Sub-types →
- Congenital nephrotic syndrome, Finnish type 0 trials
- Familial idiopathic steroid-resistant nephrotic syndrome 0 trials Sub-types →
- Nephrotic syndrome 15 0 trials
- Nephrotic syndrome 16 0 trials
- Nephrotic syndrome, IIa 26 0 trials
- Nephrotic syndrome, type 17 0 trials
- Nephrotic syndrome, type 18 0 trials
- Nephrotic syndrome, type 19 0 trials
- Nephrotic syndrome, type 20 0 trials
- Nephrotic syndrome, type 21 0 trials
- Nephrotic syndrome, type 22 0 trials
- Nephrotic syndrome, type 23 0 trials
- Nephrotic syndrome, type 24 0 trials
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Steroid-resistant nephrotic syndrome 5 trials · 15 incl. sub-types
4 sub-types
- Nephrotic syndrome of childhood - steroid sensitive 5 trials
- Nephrotic syndrome 14 3 trials
- Sporadic idiopathic steroid-resistant nephrotic syndrome 0 trials · 2 incl. sub-types Sub-types →
- Familial idiopathic steroid-resistant nephrotic syndrome 0 trials Sub-types →
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Nephrotic syndrome ocular anomalies 0 trials
Most studied deeper sub-types
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One infusion may keep childhood kidney disease at bay — a trial puts it to the test
Disease control Not yet recruitingThis trial tests whether adding a single infusion of zuberitamab to standard steroid therapy can help children aged 1 to 18 with newly diagnosed steroid-sensitive nephrotic syndrome stay relapse-free longer. Participants receive either standard steroids alone or steroids plus zub…
Phase 3 • Sponsor: Children's Hospital of Fudan University • Aim: Disease control
Last updated Aug 16, 2026 00:00 UTC
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Engineered immune cells take aim at childhood autoimmune diseases
Disease control Not yet recruitingThis early-phase trial tests a single infusion of universal CAR-T cells (RD06-05) in 30 children and adolescents with severe autoimmune diseases, including lupus, scleroderma, and kidney inflammation. The cells are designed to target and calm overactive immune cells. The main goa…
Early phase 1 • Sponsor: The Children's Hospital of Zhejiang University School of Medicine • Aim: Disease control
Last updated Jul 01, 2026 00:00 UTC
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Breakfast showdown: High-Fat vs. High-Carb – which worsens blood fats?
Knowledge-focused Not yet recruitingThis study looks at how eating a high-fat or high-carb breakfast changes fat levels in the blood over 8 hours. Researchers will compare results among people with conditions like diabetes, fatty liver, or kidney disease, as well as healthy volunteers. Participants will have two ov…
Phase 2 • Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Knowledge-focused
Last updated Sep 21, 2026 20:00 UTC
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Kidney disease drug may train immune cells to calm themselves
Knowledge-focused Not yet recruitingMembranous nephropathy is a rare autoimmune kidney disease where antibodies attack the kidney and can cause nephrotic syndrome. Rituximab is a routine treatment that depletes B cells, but researchers suspect it also boosts regulatory T cells, which help control immune reactions. …
Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Knowledge-focused
Last updated Sep 12, 2026 00:00 UTC
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A new tool to predict kidney failure risk in membranous nephropathy?
Knowledge-focused Not yet recruitingThis study is testing whether a prediction model can accurately forecast how quickly kidney function declines in people with primary membranous nephropathy, a kidney disease that can lead to nephrotic syndrome and kidney failure. Researchers will follow 128 adults with biopsy-con…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Sep 04, 2026 00:00 UTC