Nephrogenic syndrome of inappropriate antidiuresis
MONDO:0010356Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a rare genetic disorder of water balance, closely resembling the far more frequent syndrome of inappropriate antidiuretic secretion (SIAD), and characterized by euvolemic hypotonic hyponatremia due to impaired free water excretion and undetectable or low plasma arginine vasopressin (AVP) levels.
Also known as: NSIAD, nephrogenic syndrome of inappropriate antidiuresis, nephrogenic syndrome of inappropriate antidiuresis, X-linked recessive
2 clinical trials for this condition and its sub-types, 1 tagged with Nephrogenic syndrome of inappropriate antidiuresis itself.
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Diabetes drug shows promise for dangerous low sodium condition
Disease control Recruiting nowThis study tests whether the diabetes drug empagliflozin (Jardiance) can safely raise low sodium levels in people with certain conditions like SIADH, liver failure, or kidney failure. About 172 adults with chronic low sodium will receive either the drug or a placebo for up to 30 …
Phase 4 • Sponsor: University Hospital, Basel, Switzerland • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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Could a diabetes drug protect kidneys in children with genetic disease?
Disease control Recruiting nowThis study tests whether adding dapagliflozin (a diabetes drug) to standard care reduces protein leakage in the urine of children with hereditary kidney diseases. About 44 children will receive either dapagliflozin plus standard care or standard care alone for 12 weeks, then swit…
Phase 3 • Sponsor: Children's Hospital of Fudan University • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC