Neoplastic meningitis

This study tests whether a consumer smartwatch (Apple Watch or Samsung Galaxy Watch) can continuously monitor people with leptomeningeal metastasis, a condition where cancer spreads to the fluid and membranes around the brain and spinal cord. The watch collects data on movement a…

This trial tests a type of radiation called brain-avoidant proton craniospinal irradiation (BRAVO-pCSI) in people with leptomeningeal metastases, a condition where cancer spreads to the fluid and lining around the brain and spinal cord. The study includes adults with breast cance…

This phase II trial is testing whether giving the chemotherapy drug thiotepa directly into the spinal fluid—via a small device called an Ommaya reservoir—can help control cancer that has spread to the lining of the brain and spinal cord (leptomeningeal metastases) in people with …

This trial tests an oral drug called JBI-778 in people with brain metastases, leptomeningeal disease, or recurrent high-grade glioma. The drug is designed to block a protein that may help tumors grow. The study aims to find the safest dose and see if the drug can shrink tumors or…

This study tests a radioactive drug called Rhenium-186 NanoLiposome (REYOBIQ) given directly into the brain's fluid space, combined with whole brain or proton radiation. It is for people with leptomeningeal metastases, where cancer has spread to the lining of the brain and spinal…

This early study tests a new cell therapy called QH101 for people with solid tumors that have spread to the brain, spinal cord, or surrounding membranes. The therapy uses specially engineered immune cells designed to better recognize and attack cancer cells. The main goals are to…

This phase 2 trial tests a combination of the drug zorifertinib plus chemotherapy delivered directly into the fluid around the brain and spine. It is for people with a specific type of lung cancer (NSCLC with EGFR mutation) whose cancer has spread to the lining of the brain and s…

This study tests a drug called SHR-A1811 in 51 women with HER2-positive breast cancer that has spread to the brain or the lining of the brain and spinal cord. The drug is given either through a vein or directly into the spinal fluid. The goal is to see if it is safe and can shrin…

This study explores whether analyzing tumor DNA in cerebrospinal fluid can help doctors make better treatment decisions for people with malignant brain tumors or brain metastases from lung or breast cancer. Participants undergo a standard spinal tap or fluid collection, and the f…

This study follows 200 adults with stage 4 breast cancer that has spread to the brain or spinal lining. Participants fill out questionnaires about their symptoms, thinking abilities, and physical function over time. The goal is to track how symptoms change and how treatments affe…