Narcolepsy 1
MONDO:0008062A rare disorder characterized by sudden and transient episodes of loss of muscle tone. It often follows an experience of intense emotions. It is seen in patients with narcolepsy.
Also known as: HCRT narcolepsy, narcolepsy 1, narcolepsy caused by mutation in HCRT, NRCLP1, cataplexy, narcoleptic syndrome 1
33 clinical trials for this condition and its sub-types, 5 tagged with Narcolepsy 1 itself.
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New test could sharpen diagnosis of narcolepsy and related sleep disorders
Diagnosis CompletedThis study compares a new mass spectrometry technique to the standard radioimmunoassay for measuring orexin-A levels in cerebrospinal fluid. Orexin-A is a key brain chemical that is low in people with type 1 narcolepsy. The study involves 117 people with excessive daytime sleepin…
Sponsor: University Hospital, Montpellier • Aim: Diagnosis
Last updated Jul 11, 2026 00:00 UTC
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New pill aims to stop Narcolepsy's sudden muscle weakness
Symptom relief CompletedThis study tested an experimental drug called AXS-12 (reboxetine) in 90 people with narcolepsy who experience cataplexy (sudden muscle weakness) and excessive daytime sleepiness. Participants took either the drug or a placebo twice daily for several weeks. The main goal was to se…
Phase 3 • Sponsor: Axsome Therapeutics, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 12:38 UTC
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New drug shows promise for reducing narcolepsy attacks over the long term
Symptom relief CompletedThis study looked at the long-term safety and effectiveness of a drug called AXS-12 for people with narcolepsy who also have sudden muscle weakness (cataplexy) and severe daytime sleepiness. 68 people who had already completed an earlier study took AXS-12 and were monitored for s…
Phase 3 • Sponsor: Axsome Therapeutics, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 07:57 UTC
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New Once-Nightly pill could simplify narcolepsy treatment
Symptom relief CompletedThis study tested a new once-nightly medication called FT218 for people with narcolepsy who experience excessive daytime sleepiness and sudden muscle weakness (cataplexy). It included 184 participants, some already on a twice-nightly medication and some new to treatment. The goal…
Phase 3 • Sponsor: Avadel • Aim: Symptom relief
Last updated Jun 27, 2026 07:53 UTC