Myalgic encephalomeyelitis/chronic fatigue syndrome
MONDO:0005404A medical condition characterized by long-term fatigue and other symptoms that limit a person's ability to carry out ordinary daily activities.
Also known as: CFS, chronic fatigue immune dysfunction syndrome, chronic fatigue syndrome, myalgic encephalitis, myalgic encephalomyelitis, systemic exertion intolerance disease
75 clinical trials for this condition and its sub-types, 75 tagged with Myalgic encephalomeyelitis/chronic fatigue syndrome itself.
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Can a cancer drug reboot the immune system in chronic fatigue syndrome?
Disease control Not yet recruitingThis trial tests whether inebilizumab, an antibody that wipes out certain immune cells called B cells, can improve physical function in adults with ME/CFS that started after an infection. Participants receive three infusions over six months, and the study measures changes in mobi…
Phase 2 • Sponsor: Charite University, Berlin, Germany • Aim: Disease control
Last updated Jul 26, 2026 00:00 UTC
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Could a tiny dose of naltrexone ease ME/CFS fatigue?
Symptom relief Not yet recruitingThis study tests whether a low dose of naltrexone can reduce fatigue in people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Researchers will enroll 75 adults from Alabama and track their fatigue levels weekly through online surveys. The goal is to find the be…
Phase 2 • Sponsor: University of Alabama at Birmingham • Aim: Symptom relief
Last updated Aug 23, 2026 00:00 UTC
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Ancient remedy meets modern prebiotic: a new hope for Shift-Worker fatigue?
Symptom relief Not yet recruitingThis trial is testing whether a combination of Bao Yuan Tang, a traditional Chinese medicine extract, and galactooligosaccharides, a type of prebiotic, can improve sleep quality, reduce fatigue, and support better metabolism in female nurses who work night shifts. The study will …
Sponsor: Hepatopancreatobiliary Surgery Institute of Gansu Province • Aim: Symptom relief
Last updated Aug 21, 2026 00:00 UTC
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Could breathing different oxygen levels ease chronic fatigue?
Symptom relief Not yet recruitingThis study tests a treatment called Intermittent Hypoxia-Hyperoxia Treatment (IHHT) for people with ME/CFS or long COVID. The therapy uses a mask to deliver short cycles of low and high oxygen, aiming to improve energy and reduce inflammation. 104 patients will be randomly assign…
Sponsor: University of Aarhus • Aim: Symptom relief
Last updated Jun 27, 2026 12:37 UTC
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Could a magnetic headset boost brain power after injury or illness?
Symptom relief Not yet recruitingThis early study tests whether a low-level magnetic therapy device, used at home, is safe and practical for people with cognitive issues from brain injury, Long COVID, or Alzheimer's. About 30 adults will use the device regularly and complete computer-based thinking tests. The go…
Sponsor: Icahn School of Medicine at Mount Sinai • Aim: Symptom relief
Last updated Jun 27, 2026 12:35 UTC
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New program aims to help breast cancer patients stick with treatment by easing pain
Symptom relief Not yet recruitingThis study tests a program called AIMSS-CARE for breast cancer patients who have joint and muscle pain from their hormone therapy. The program includes exercise, education, symptom tracking, and follow-up. Eighty-eight patients in Ethiopia will be randomly assigned to the program…
Sponsor: Addis Ababa University • Aim: Symptom relief
Last updated Jun 27, 2026 09:04 UTC
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Acupuncture needles aim to clear COVID brain fog in new trial
Symptom relief Not yet recruitingThis study tests whether acupuncture can improve thinking and memory problems (brain fog) in people with chronic fatigue syndrome (ME/CFS) that started after COVID-19. About 99 adults will be randomly assigned to real acupuncture, fake acupuncture, or a waiting list for 8 weeks. …
Sponsor: Xi Wu • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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Can a phone app beat standard care for MS fatigue?
Symptom relief Not yet recruitingThis study tests whether a digital tool called MSCopilot Boost can reduce the impact of fatigue in people with multiple sclerosis better than standard care. The tool includes remote monitoring of walking, dexterity, vision, and cognition, plus a personalized telerehabilitation pr…
Sponsor: Ad scientiam • Aim: Symptom relief
Last updated Jun 27, 2026 07:53 UTC