Multiple system atrophy

MONDO:0007803

Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by autonomic failure (cardiovascular and/or urinary), parkinsonism, cerebellar impairment and corticospinal signs with a median survival of 6-9 years.

Also known as: MSA, Shy-Drager syndrome, multisystem atrophy, Shy-dragger syndrome (formerly), autonomic failure, Pure, hypotension, orthostatic, susceptibility to multiple system atrophy 1

131 clinical trials for this condition and its sub-types, 110 tagged with Multiple system atrophy itself.

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Where it sits in the disease tree

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Part of

↑ Movement disorder (805) ↑ Synucleinopathy (237)

Sub-types of Multiple system atrophy

Pure autonomic failure 18 trials
Multiple system atrophy, parkinsonian type 12 trials
Multiple system atrophy, cerebellar type 3 trials
Striatonigral degeneration 0 trials
3 sub-types
- Familial infantile bilateral striatal necrosis 0 trials Sub-types →
- Striatal degeneration, autosomal dominant 0 trials Sub-types →
- Striatonigral degeneration, childhood-onset 0 trials

Most studied deeper sub-types

Autosomal dominant striatal neurodegeneration type 1 (0) Striatal degeneration, autosomal dominant 2 (0) Striatonigral degeneration, infantile, mitochondrial (0)

Including sub-types (131) Tagged with Multiple system atrophy (110)

Trials to join now! 67 Not yet recruiting 13 Not yet finished but already full! 23 Completed 27 Terminated 1

Scientists probe hidden danger of low blood sugar in diabetes

Knowledge-focused Stopped early

This study looked at why people with type 1 diabetes often fail to sense dangerously low blood sugar (hypoglycemia). Researchers tested how opioid drugs like morphine and naloxone affect the body's ability to respond to low sugar. The goal was to better understand the problem, no…

Phase 2 • Sponsor: Albert Einstein College of Medicine • Aim: Knowledge-focused

Last updated Jun 27, 2026 12:35 UTC

Multiple system atrophy

Where it sits in the disease tree

Most studied deeper sub-types

Scientists probe hidden danger of low blood sugar in diabetes