Metastatic malignant neoplasm in the spinal cord

This study tests whether combining two treatments—thermal ablation (using heat to destroy tumor cells) and stereotactic radiosurgery (precise, high-dose radiation)—can better control cancer that has spread to the spine and is pressing on the spinal cord. About 60 adults with vari…

This early-phase study tests whether a single, precise session of radiation (spine stereotactic radiosurgery) can safely treat spinal cord compression caused by cancer that has spread to the spine. The study includes 43 adults with inoperable tumors pressing on the spinal cord. R…

This early-phase trial tested whether giving a second, single dose of highly focused radiation is safe for people with spine tumors that have grown back after previous radiation. Nine adults with certain types of cancer took part. The goal was to find the highest safe dose and wa…

This study tests whether injecting bone cement into the spine can prevent fractures after high-dose radiation treatment for cancer that has spread to the backbone. About 87 patients with solid tumors and spinal metastases will receive either standard radiation alone or radiation …

This study tests whether a single large dose of spine radiosurgery works better than three smaller doses for people whose spinal tumors have come back after previous radiation. About 80 adults with solid tumors that spread to the spine will be randomly assigned to one of the two …

This study tests a highly precise radiation system (CT-on-Rails or Trilogy) to treat spine tumors that have spread from other cancers. About 150 participants will receive three radiation sessions over two weeks. Researchers will track pain relief and side effects using patient qu…

This study looks at whether doing MRI scans in the same position used for radiation treatment helps doctors plan more accurate therapy for spinal tumors. About 21 adults with cancer that has spread to the spine will have two MRI scans—one with a special immobilization device and …

This study is a registry that collects medical records, quality-of-life questionnaires, and tissue samples from 900 people with spine tumors or other spine disorders. The goal is to learn more about these conditions to guide better treatment in the future. Participants must be be…

This study looks at three ways surgeons place screws in the spine during surgery: using a robot, using a navigation system, or doing it by hand. The goal is to see which method leads to fewer screws needing to be fixed in a second surgery within the first year. About 932 adults w…

This study is a registry that gathers detailed information from about 960 adults with metastatic spine tumors (cancer that has spread to the spine from elsewhere). Researchers collect data on patients' health, treatments, symptoms, and quality of life over time. The goal is to be…