Mayer-Rokitansky-Kuster-Hauser syndrome
MONDO:0017771Spectrum of Mullerian duct anomalies characterized by congenital aplasia of the uterus and upper 2/3 of the vagina in otherwise phenotypically normal females. It can be classified as either MRKH syndrome type 1 (corresponding to isolated utero-vaginal aplasia) or MRKH syndrome type 2 (utero-vaginal aplasia associated with other malformations).
Also known as: MRKH, MRKH syndrome, Mayer-Rokitansky-Küster-Hauser Syndrome, Mullerian aplasia/dysgenesis, Rokitansky Kuster Hauser syndrome, Rokitansky syndrome, Mayer-Rokitansky-Küster-Hauser syndrome
9 clinical trials for this condition and its sub-types, 8 tagged with Mayer-Rokitansky-Kuster-Hauser syndrome itself.
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Browse by category →Sub-types of Mayer-Rokitansky-Kuster-Hauser syndrome
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Womb transplant trial offers hope for women born without a uterus
Disease control Recruiting nowThis study tests whether a donated uterus can help 10 women who were born without a uterus or had it removed to carry a pregnancy. Participants will receive a uterus from a living or deceased donor, then try in vitro fertilization (IVF) to become pregnant. The goal is a live birt…
Sponsor: John Goss • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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Lab-Grown vaginas: first human trial launches
Disease control Recruiting nowThis Phase 1 trial tests a lab-grown vaginal implant made from a patient's own cells for women with vaginal aplasia (born without a vagina). Ten participants will receive the implant to see if it is safe and can improve quality of life. The implant is designed to mimic natural va…
Phase 1 • Sponsor: Wake Forest University Health Sciences • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Can better understanding of womb shape anomalies improve fertility outcomes?
Knowledge-focused Recruiting nowThis study follows 1,500 women with mullerian anomalies — differences in the shape or structure of the uterus, cervix, or vagina. Researchers aim to learn how these variations affect fertility, pregnancy, and the success of surgical treatments. The goal is to improve diagnosis an…
Sponsor: University Hospital, Ghent • Aim: Knowledge-focused
Last updated Aug 01, 2026 00:00 UTC
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New study aims to understand the emotional and sexual well-being of women with a rare uterine condition
Knowledge-focused Recruiting nowThis study looks at how Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, a rare condition where the uterus and vagina are underdeveloped, affects women's overall quality of life, sexual health, and mental well-being. Researchers will compare 102 women with MRKH to a control group …
Sponsor: University Hospital, Toulouse • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC