Malignant pleural mesothelioma

This early-phase trial is testing an experimental drug called BMS-986504 alongside standard cancer treatments in 60 people with advanced cancers that have lost a gene called MTAP. The cancers include mesothelioma, stomach/esophageal cancer, and bladder cancer. The main goal is to…

Researchers are testing two experimental oral drugs, TT-10 and TT-4, in adults with advanced solid tumors such as kidney, prostate, and lung cancers that have worsened after standard treatment or cannot receive it. The drugs block adenosine receptors, which tumors use to quiet th…

This phase 2 trial is testing an experimental drug called volrustomig, either alone or with chemotherapy, in people with advanced cervical, head and neck, esophageal, or mesothelioma cancers. The study aims to see if the drug can shrink tumors and how safe it is. About 257 partic…

This study tests whether adding an experimental immunotherapy (fianlimab) to standard treatment (cemiplimab plus chemotherapy) can better control pleural mesothelioma, a rare and aggressive cancer of the lung lining. About 126 people who have not yet been treated will receive one…

This phase 2 trial tests a drug called ivonescimab in 38 people with pleural mesothelioma whose cancer has returned after immunotherapy and chemotherapy. The drug works by blocking blood vessel growth and boosting the immune system to fight cancer. The main goal is to see if the …

This early-phase trial is testing an experimental oral drug called APG-2449 in people with advanced solid tumors, including certain lung cancers, mesothelioma, esophageal cancer, and ovarian cancer. APG-2449 is designed to block several proteins (FAK, ALK, and ROS1) that help can…

This early-stage trial tests an experimental drug called SAR445877, alone or with other cancer drugs, in adults with advanced solid tumors that have spread or cannot be removed. The study has two parts: first, finding a safe dose, and second, checking if the drug shrinks tumors. …

This early-phase study tests a new drug called CT-95 in people with advanced cancers that have a protein called mesothelin on their cells. The main goals are to find a safe dose and see if the drug can shrink tumors. About 70 adults with ovarian, lung, pancreatic, or other mesoth…

This early-phase trial is testing whether adding an immunotherapy drug (atezolizumab) and a personalized vaccine (WT1/DC) to standard chemotherapy can safely improve outcomes for people with a rare type of mesothelioma. The study plans to enroll 15 adults with epithelioid maligna…

This study tests a drug called sacituzumab govitecan in 33 adults with mesothelioma that has come back or spread. Participants receive the drug until their disease worsens or side effects become too severe. The main goal is to see if the drug can shrink tumors and help control th…

This early-phase trial tests a new treatment for people with mesothelioma that cannot be removed by surgery or has come back after standard therapy. The treatment uses donor immune cells (natural killer cells) that are engineered in a lab to recognize and attack two proteins foun…

This study tests whether proton beam therapy can help people with a rare cancer called malignant pleural mesothelioma. It involves 148 adults whose cancer is on one side of the chest. The goal is to see if this treatment can slow the cancer and help people live longer with fewer …

This early-phase trial tests whether adding the immunotherapy drug pembrolizumab and a special imaging technique during surgery can improve treatment for malignant pleural mesothelioma, a rare and aggressive lung cancer. About 20 adults with measurable disease will receive the co…

This study tests whether giving immunotherapy drugs (durvalumab and tremelimumab) alone or with chemotherapy before surgery can help prevent pleural mesothelioma from coming back. About 52 people with potentially removable tumors will take part. The main goal is to see if more th…

This study tests a new two-step treatment for people with malignant pleural mesothelioma, a rare and serious cancer of the lung lining. First, doctors use a special light therapy during a scope procedure to kill cancer cells. Then, patients receive an immunotherapy drug called ni…

This early-stage trial tests a new drug called NX-1607 in adults with advanced cancers that have not responded to standard treatments. The study aims to find a safe dose and see if the drug can shrink tumors. It includes people with several cancer types, such as ovarian, lung, an…

This study is testing a new breath test, called an electronic nose (E-Nose), to see if it can measure how well treatment is working for people with malignant pleural mesothelioma (MPM). Researchers will collect breath samples from 20 patients before and during standard treatment,…

This study looks at whether a surgery called partial pleurectomy (removing part of the lung lining) can help with symptoms and quality of life in people with advanced pleural mesothelioma that cannot be fully removed. About 30 participants will have the surgery and fill out sympt…

This study aims to collect tumor, normal tissue, and blood samples from up to 1559 people with cancers of the lung, esophagus, or pleura. Researchers will analyze genetic and epigenetic changes to better understand these diseases and identify potential markers for future treatmen…

This observational study collects tumor tissue and blood cells from 200 people with advanced solid tumors like colorectal, lung, and pancreatic cancers. The goal is to understand how often tumors lose a specific marker (HLA) and to store participants' own T cells for potential fu…

This research study is collecting tissue samples from 240 adults with malignant pleural mesothelioma to test a new method that combines molecular, radiological, and blood tests. The goal is to create a score that helps doctors predict how the disease will progress. Participants m…

This study looks at the immune system inside malignant pleural mesothelioma, a rare and hard-to-treat cancer. Researchers will analyze tumor samples from 300 adults to understand why immunotherapy helps only some patients. The goal is to find clues that could make these treatment…

This study is looking at tumor samples from 220 people with pleural or peritoneal mesothelioma, a rare cancer linked to asbestos. Researchers will analyze the genes and immune cells in these tumors to find patterns that could predict which treatments work best. The goal is to imp…