Malignant germ cell tumor
MONDO:0006290A gonadal or extragonadal malignant neoplasm that arises from germ cells. Representative examples include embryonal carcinoma, yolk sac tumor, and seminoma.
Also known as: cancer of germ cell, germ cell cancer, germ cell tumor, malignant, malignant germ cell neoplasm, malignant germ cell tumor, malignant neoplasm of germ cell, malignant neoplasm of the germ cell, malignant tumor of germ cell
2802 clinical trials for this condition and its sub-types, 15 tagged with Malignant germ cell tumor itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Malignant germ cell tumor
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Malignant testicular germ cell tumor 14 trials · 36 incl. sub-types
6 sub-types
- Testis refractory cancer 13 trials
- Testicular seminoma 8 trials Sub-types →
- Testicular non-seminomatous germ cell cancer 3 trials · 4 incl. sub-types Sub-types →
- Mixed testicular germ cell cancer 2 trials Sub-types →
- Malignant teratoma of testis 0 trials
- Testis polyembryoma 0 trials
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Seminoma 22 trials
2 sub-types
- Testicular seminoma 8 trials Sub-types →
- Extragonadal seminoma 1 trial Sub-types →
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Extragonadal germ cell cancer 0 trials · 22 incl. sub-types
9 sub-types
- Extragonadal nonseminomatous germ cell tumor 5 trials · 19 incl. sub-types Sub-types →
- Extragonadal germinoma 0 trials · 4 incl. sub-types Sub-types →
- Malignant pineal area germ cell neoplasm 2 trials · 3 incl. sub-types Sub-types →
- Extragonadal seminoma 1 trial Sub-types →
- Mediastinal malignant germ cell tumor 1 trial Sub-types →
- Malignant cardiac germ cell tumor 0 trials
- Malignant gastric germ cell tumor 0 trials Sub-types →
- Malignant peritoneal germ cell tumor 0 trials
- Mixed extragonadal germ cell cancer 0 trials Sub-types →
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Germinoma 7 trials · 9 incl. sub-types
1 sub-type
- Extragonadal germinoma 0 trials · 4 incl. sub-types Sub-types →
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Mixed germ cell tumor 3 trials · 5 incl. sub-types
6 sub-types
- Mixed testicular germ cell cancer 2 trials Sub-types →
- Mixed extragonadal germ cell cancer 0 trials Sub-types →
- Mixed germ cell tumor of vulva 0 trials
- Mixed teratoma and seminoma 0 trials
- Ovarian mixed germ cell neoplasm 0 trials
- Teratocarcinoma 0 trials
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Malignant germ cell tumor of ovary 2 trials · 4 incl. sub-types
4 sub-types
- Ovarian primitive germ cell tumor 0 trials · 2 incl. sub-types Sub-types →
- Choriocarcinoma of ovary 1 trial Sub-types →
- Malignant dysgerminomatous germ cell tumor of ovary 0 trials
- Primary non-gestational choriocarcinoma of ovary 0 trials
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Malignant teratoma 1 trial · 3 incl. sub-types
7 sub-types
- Immature ovarian teratoma 1 trial · 2 incl. sub-types Sub-types →
- Pineal region immature teratoma 1 trial
- Immature extragonadal teratoma 0 trials
- Immature gastric teratoma 0 trials
- Intermediate malignant teratoma 0 trials
- Malignant teratoma of mediastinum 0 trials
- Malignant teratoma of testis 0 trials
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Malignant childhood germ cell neoplasm 0 trials · 3 incl. sub-types
12 sub-types
- Childhood central nervous system germinoma 1 trial Sub-types →
- Childhood endodermal sinus tumor 0 trials · 1 incl. sub-types Sub-types →
- Childhood immature teratoma of ovary 1 trial
- Childhood central nervous system embryonal carcinoma 0 trials
- Childhood central nervous system mixed germ cell tumor 0 trials
- Childhood choriocarcinoma of the ovary 0 trials
- Childhood embryonal testis carcinoma 0 trials
- Childhood ovarian embryonal carcinoma 0 trials
- Childhood testicular choriocarcinoma 0 trials
- Childhood testicular mixed germ cell cancer 0 trials Sub-types →
- Pediatric CNS choriocarcinoma 0 trials
- Pediatric ovarian dysgerminoma 0 trials
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Dysgerminoma 1 trial
2 sub-types
- Dysgerminoma of ovary 0 trials Sub-types →
- Pineal region dysgerminoma 0 trials
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1 sub-type
- Uterine corpus choriocarcinoma 0 trials
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Pulmonary artery choriocarcinoma 0 trials
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Vaginal germ cell malignant tumor 0 trials
1 sub-type
- Vaginal yolk sac tumor 0 trials
Most studied deeper sub-types
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New hope for kids with tough cancers: targeted drug attacks gene flaw
Disease control OngoingThis study tests a drug called ulixertinib in children and teens whose advanced cancers have a specific genetic change in the MAPK pathway. The goal is to see if the drug can shrink or control the tumor. About 20 participants with various solid tumors, lymphomas, or related disor…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Sep 21, 2026 16:00 UTC
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New hope for kids with rare cancers: targeted drug selpercatinib tested in phase 2 trial
Disease control OngoingThis phase 2 trial tests the drug selpercatinib in children and young adults (ages 1 to 21) with advanced cancers that have a specific genetic change called a RET alteration. The goal is to see if the drug can shrink tumors or stop them from growing. Only one participant has been…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Aug 05, 2026 00:00 UTC
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Rare cancer hope: immune drug shows promise in phase 2 trial
Disease control OngoingThis study tested a drug called pembrolizumab in 157 people with rare cancers that had spread or couldn't be removed. The drug works by helping the body's immune system attack the cancer. The main goal was to see how many patients were alive and their cancer hadn't grown after 27…
Phase 2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jul 19, 2026 00:00 UTC
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Targeted drug shows promise for kids with Tough-to-Treat cancers
Disease control OngoingThis study tested the drug ensartinib in 13 children and young adults (ages 1–21) whose cancers had come back or did not respond to treatment and had specific ALK or ROS1 gene changes. The goal was to see if the drug could shrink or stop tumor growth. While the drug targets cance…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
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New hope for kids with rare cancers: targeted drug larotrectinib tested in small trial
Disease control OngoingThis phase 2 trial is testing the drug larotrectinib in children and young adults (ages 1 to 21) with advanced solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that have a specific genetic change called an NTRK fusion. The cancers have either come back after treatment…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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High-Dose chemo with stem cell transplant tested against standard therapy for tough germ cell cancers
Disease control OngoingThis phase 3 trial compares two chemotherapy approaches for people with germ cell tumors that have returned or not responded to initial treatment. One group receives standard-dose chemotherapy with paclitaxel, ifosfamide, and cisplatin (TIP). The other receives high-dose chemothe…
Phase 3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Can DNA tests pick the right cancer drug for kids?
Knowledge-focused OngoingThis study screens children and teens with advanced solid tumors, lymphomas, or histiocytic disorders to find genetic changes in their cancer cells. Participants undergo biopsies and scans to identify mutations that can be targeted by specific drugs. The goal is to see if matchin…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Jul 26, 2026 00:00 UTC