Malignant choroid melanoma
MONDO:0003878A uveal melanoma that arises from the choroid. It is the most common primary malignant intraocular tumor. It usually affects Caucasians of northern European descent. It usually remains asymptomatic for a long period. When signs and symptoms occur, they include blurred vision, visual field loss, floaters, and ocular pain. Tumor size is the most important factor that relates to prognosis.
Also known as: choroid malignant melanoma, choroid melanoma, choroidal melanoma, malignant melanoma of choroid, malignant melanoma of the choroid, melanoma (disease) of optic choroid, melanoma of choroid, melanoma of the choroid
2851 clinical trials for this condition and its sub-types, 10 tagged with Malignant choroid melanoma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Malignant choroid melanoma
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Choroid epithelioid cell melanoma 0 trials
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Choroid mixed cell melanoma 0 trials
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Choroid necrotic melanoma 0 trials
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Choroid spindle cell melanoma 0 trials
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New eye injection could spare sight in melanoma patients
Disease control OngoingThis Phase 3 trial tests a new drug called belzupacap sarotalocan (AU-011) for people with small choroidal melanoma or suspicious spots in the eye. The drug is injected into the eye and activated by a laser to target cancer cells. The study compares it to a sham (fake) procedure …
Phase 3 • Sponsor: Aura Biosciences • Aim: Disease control
Last updated Aug 02, 2026 00:00 UTC
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Liver-Directed chemo shows promise for eye cancer metastases
Disease control OngoingThis phase 2 trial tests a procedure called transarterial chemoembolization (TACE) for people with uveal melanoma that has spread to the liver. Doctors inject a chemotherapy drug (carmustine) mixed with an oily contrast agent (Lipiodol) directly into the liver's blood supply, the…
Phase 2 • Sponsor: Thomas Jefferson University • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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New combo therapy aims to shrink eye tumors before radiation
Disease control By invitation onlyThis early-phase trial tests whether injecting the chemotherapy drug melphalan directly into the eye's blood vessels can shrink large uveal melanomas (eye cancers) enough to then treat them with radiation. Ten adults with tumors at least 8 mm thick will receive the chemo injectio…
Phase 1/2 • Sponsor: Hospital das Clínicas de Ribeirão Preto • Aim: Disease control
Last updated Jun 26, 2026 17:03 UTC
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Researchers track Long-Term safety of experimental eye cancer treatment
Knowledge-focused By invitation onlyThis study is a long-term follow-up for 100 people who completed a previous trial of bel-sar, an experimental treatment for early choroidal melanoma (a type of eye cancer). Participants will not receive any new treatment but will be monitored for about 5 more years to check for s…
Sponsor: Aura Biosciences • Aim: Knowledge-focused
Last updated Aug 21, 2026 00:00 UTC
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Researchers track Long-Term safety of experimental eye cancer drug
Knowledge-focused OngoingThis registry follows 63 patients with choroidal melanoma or early eye lesions who were treated with the experimental drug bel-sar in earlier studies. The goal is to monitor long-term safety, side effects, and any spread of the disease over time. Participants are not receiving ne…
Sponsor: Aura Biosciences • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC