Machado-Joseph disease
MONDO:0007182Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease, is the most common subtype of type 1 autosomal dominant cerebellar ataxia (ADCA type 1), a neurodegenerative disorder, and is characterized by ataxia, external progressive ophthalmoplegia, and other neurological manifestations.
Also known as: Azorean disease of the nervous system, MJD, Machado disease, Machado-Joseph disease, Nigro-spino-dentatal degeneration with nuclear ophthalmoplegia, SCA3, autosomal dominant striatonigral degeneration, spinocerebellar ataxia 3
30 clinical trials for this condition and its sub-types, 11 tagged with Machado-Joseph disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Machado-Joseph disease
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Machado-Joseph disease type 3 2 trials
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Machado-Joseph disease type 1 0 trials
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Machado-Joseph disease type 2 0 trials
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Machado-Joseph disease type 4 0 trials
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Hope for ataxia: experimental drug shows promise in Late-Stage trial
Disease control CompletedThis study tested a drug called troriluzole in 141 adults with spinocerebellar ataxia, a rare disease that affects balance and coordination. Participants took either the drug or a placebo daily for 8 weeks. The main goal was to see if troriluzole could improve symptoms like walki…
Phase 2/3 • Sponsor: Biohaven Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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New blood test could replace risky prenatal procedures for genetic diseases
Diagnosis CompletedThis study aimed to develop a non-invasive prenatal test using fetal cells from a mother's blood to detect triplet repeat diseases like Huntington's disease, Fragile X syndrome, and certain types of muscular dystrophy and ataxia. Researchers enrolled 60 pregnant women at risk and…
Sponsor: University Hospital, Montpellier • Aim: Diagnosis
Last updated Jun 27, 2026 07:53 UTC
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Hunting for the first clues of a devastating brain disease
Knowledge-focused CompletedThis study follows people who have a 50% chance of inheriting a gene for spinocerebellar ataxia, a group of progressive brain disorders that affect movement and coordination. The goal is to identify the earliest clinical signs and biological markers that appear before the disease…
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Aug 21, 2026 00:00 UTC