Liver disorder
MONDO:0005154A disease involving the liver.
Also known as: disease of liver, disease or disorder of liver, disorder of liver, hepatic disease, hepatic disorder, liver and intrahepatic bile duct disorder, liver disease, liver disease or disorder
3621 clinical trials for this condition and its sub-types, 324 tagged with Liver disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Liver disorder
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Liver and intrahepatic bile duct neoplasm 78 trials · 1,752 incl. sub-types
17 sub-types
- Liver cancer 255 trials · 1,708 incl. sub-types Sub-types →
- Biliary tract neoplasm 31 trials · 627 incl. sub-types Sub-types →
- Liver hemangioma 6 trials Sub-types →
- Undifferentiated embryonal sarcoma of the liver 6 trials
- Hepatocellular adenoma 2 trials Sub-types →
- Fibrohistiocytic inflammatory pseudotumor of the liver 0 trials
- Hepatic angiomyolipoma 0 trials
- Hepatic granuloma 0 trials
- Inflammatory pseudotumor of the liver 0 trials
- Liver adenomatosis 0 trials
- Liver inflammatory myofibroblastic tumor 0 trials
- Liver leiomyoma 0 trials Sub-types →
- Liver lipoma 0 trials Sub-types →
- Liver mesenchymal hamartoma 0 trials
- Liver solitary fibrous tumor 0 trials
- Lymphoplasmacytic inflammatory pseudotumor of the liver 0 trials
- Solitary necrotic nodule of the liver 0 trials
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Hepatitis 51 trials · 734 incl. sub-types
9 sub-types
- Viral hepatitis 12 trials · 443 incl. sub-types Sub-types →
- Metabolic dysfunction-associated steatohepatitis 232 trials
- Alcoholic hepatitis 32 trials
- Autoimmune hepatitis 30 trials · 31 incl. sub-types Sub-types →
- Drug-induced hepatitis 3 trials
- Fulminant viral hepatitis 3 trials
- Granulomatous hepatitis 0 trials
- Hepatic tuberculosis 0 trials
- Idiopathic peliosis hepatis 0 trials
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Fatty liver disease 154 trials · 617 incl. sub-types
4 sub-types
- Metabolic dysfunction-associated steatotic liver disease 508 trials · 573 incl. sub-types Sub-types →
- Alcoholic fatty liver disease 14 trials
- Metabolic dysfunction and alcohol associated liver disease 8 trials
- Visceral steatosis, congenital 5 trials
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Cirrhosis of liver 522 trials · 602 incl. sub-types
3 sub-types
- Cirrhosis, familial 4 trials · 79 incl. sub-types Sub-types →
- Alcoholic liver cirrhosis 21 trials
- Hepatitis C induced liver cirrhosis 5 trials
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Liver failure 71 trials · 199 incl. sub-types
3 sub-types
- Chronic liver failure 125 trials
- Acute liver failure 18 trials Sub-types →
- Infantile liver failure 0 trials · 1 incl. sub-types Sub-types →
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Hepatic vascular disorder 1 trial · 116 incl. sub-types
11 sub-types
- Portal hypertension 90 trials
- Portal vein thrombosis 18 trials
- Hepatic veno-occlusive disease 6 trials Sub-types →
- Fontan-associated liver disease 5 trials
- Portosinusoidal vascular disease 3 trials Sub-types →
- Budd-Chiari syndrome 1 trial
- Nutmeg liver 1 trial
- Hepatic infarction 0 trials
- Hepatic vein thrombosis 0 trials
- Liver angiosarcoma 0 trials
- Peliosis hepatis 0 trials
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Fibrotic liver disease 96 trials
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Alcoholic liver disease 44 trials · 88 incl. sub-types
3 sub-types
- Alcoholic hepatitis 32 trials
- Alcoholic liver cirrhosis 21 trials
- Alcoholic fatty liver disease 14 trials
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Drug-induced liver injury 22 trials · 24 incl. sub-types
1 sub-type
- Drug-induced hepatitis 3 trials
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Hepatic porphyria 4 trials · 23 incl. sub-types
7 sub-types
- Erythropoietic protoporphyria 15 trials Sub-types →
- HMBS-related hepatic porphyria 0 trials · 5 incl. sub-types Sub-types →
- Hereditary coproporphyria 5 trials
- PPOX-related hepatic porphyria 0 trials · 2 incl. sub-types Sub-types →
- Porphyria cutanea tarda 0 trials · 1 incl. sub-types Sub-types →
- Hepatic cutaneous porphyria 0 trials
- Porphyria due to ALA dehydratase deficiency 0 trials
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Familial intrahepatic cholestasis 1 trial · 17 incl. sub-types
4 sub-types
- Progressive familial intrahepatic cholestasis 16 trials · 17 incl. sub-types Sub-types →
- Benign recurrent intrahepatic cholestasis 2 trials · 5 incl. sub-types Sub-types →
- Cholestasis, intrahepatic, of pregnancy, 1 0 trials
- Cholestasis, intrahepatic, of pregnancy, 3 0 trials
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Hepatorenal syndrome 13 trials
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Bile duct cyst 10 trials
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Liver abscess (disease) 4 trials
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5 sub-types
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Glycogen storage disease due to liver phosphorylase kinase deficiency 0 trials · 2 incl. sub-types
2 sub-types
- Glycogen storage disease IXa1 2 trials
- Glycogen storage disease IXc 2 trials
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Aagenaes syndrome 1 trial
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Hepatoportal sclerosis 0 trials
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Hepatopulmonary syndrome 0 trials
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Hyperbiliverdinemia 0 trials
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Liver disease, severe congenital 0 trials
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Polycystic echinococcosis 0 trials
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Primitive portal vein thrombosis 0 trials
Most studied deeper sub-types
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Experimental liver drug shows early promise but trial cut short
Disease control Stopped earlyThis early study tested a drug called VS-01 in 15 adults with acute-on-chronic liver failure (a sudden worsening of liver function) and fluid buildup in the belly. Participants received either VS-01 plus standard care or standard care alone. The trial was terminated early, so we …
Phase 2 • Sponsor: Genfit • Aim: Disease control
Last updated Jul 25, 2026 00:00 UTC
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Heart drug digoxin tested for alcoholic hepatitis – early trial halted
Disease control Stopped earlyThis small, early-phase study tested whether the heart medication digoxin could reduce inflammation in people with severe alcohol-associated hepatitis. 23 participants were randomly assigned to receive intravenous digoxin or no digoxin for up to 28 days. The trial was terminated …
Phase 2 • Sponsor: Yale University • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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New drug combo aims to lower liver vein pressure in cirrhosis patients
Disease control Stopped earlyThis study tested whether the drug Avenciguat, taken alone or with empagliflozin, can lower high blood pressure in the portal vein (the main vessel to the liver) in people with cirrhosis. About 90 adults with cirrhosis from hepatitis or fatty liver disease were enrolled. The tria…
Phase 2 • Sponsor: Boehringer Ingelheim • Aim: Disease control
Last updated Jun 26, 2026 14:08 UTC
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Blood RNA may reveal hidden liver cancers
Diagnosis Stopped earlyThis study looked at whether tiny bits of RNA in the blood can serve as markers for liver disease and liver cancer. Researchers collected blood samples from nearly 1,900 people with liver cancer, cirrhosis, or chronic liver disease. The goal was to see if these RNA markers could …
Sponsor: Mayo Clinic • Aim: Diagnosis
Last updated Jun 27, 2026 12:29 UTC
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Ear device aims to cut opioid use after liver transplant
Symptom relief Stopped earlyThis study tested a small device worn on the ear that uses mild electrical pulses to help control pain after a liver transplant. The goal was to see if it could reduce the need for strong painkillers like opioids. The study was stopped early and included 27 adults waiting for a l…
Sponsor: Duke University • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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Alcohol and cirrhosis: can a quick test spot brain problems?
Knowledge-focused Stopped earlyThis study aimed to see if a short test called BEARNI could detect alcohol-related cognitive impairments (like memory and thinking problems) in people with alcoholic cirrhosis. The researchers planned to enroll patients with cirrhosis, but the study was stopped early after only o…
Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
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Liver impairment study for cancer drug tazemetostat halted early
Knowledge-focused Stopped earlyThis study looked at how the cancer drug tazemetostat is processed in the body of people with advanced solid tumors who also have moderate or severe liver impairment. Researchers compared drug levels in these patients to those with normal liver function. The trial was terminated …
Phase 1 • Sponsor: Epizyme, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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Cystic fibrosis study aims to build a research database, not test a cure
Knowledge-focused Stopped earlyThis study is for people with cystic fibrosis and their family members. Its goal is to collect medical information and biological samples during regular clinic visits. These will be stored and used by researchers to learn more about how cystic fibrosis affects the body and how it…
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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Liver study of cancer drug amcenestrant halted early
Knowledge-focused Stopped earlyThis early-stage study looked at how the drug amcenestrant is processed in the body of women aged 40-75 with mild or moderate liver problems, compared to women with healthy livers. The goal was to understand dosing and safety. However, the trial was terminated before completion, …
Phase 1 • Sponsor: Sanofi • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC
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Hepatitis b patients under the microscope: new study observes Real-World treatments
Knowledge-focused Stopped earlyThis study observed over 1,700 adults with chronic hepatitis B in the US and Canada to understand how the disease progresses and how treatments are used in everyday medical practice. Researchers collected data from both academic and community clinics to build a real-world picture…
Sponsor: Target PharmaSolutions, Inc. • Aim: Knowledge-focused
Last updated Jun 26, 2026 18:05 UTC