Lipodystrophy
MONDO:0006573A congenital or acquired disorder characterized by abnormal loss or redistribution of the adipose tissue in the body.
Also known as: lipodsystrophic syndrome, lipodsystrophic syndromes, lipodystrophy, lipodystrophy (disease)
48 clinical trials for this condition and its sub-types, 30 tagged with Lipodystrophy itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Lipodystrophy
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Partial lipodystrophy 7 trials · 19 incl. sub-types
2 sub-types
- Familial partial lipodystrophy 13 trials · 14 incl. sub-types Sub-types →
- Acquired partial lipodystrophy 6 trials
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Hereditary lipodystrophy 2 trials · 17 incl. sub-types
11 sub-types
- Familial partial lipodystrophy 13 trials · 14 incl. sub-types Sub-types →
- Congenital generalized lipodystrophy 2 trials · 3 incl. sub-types Sub-types →
- Berardinelli-Seip congenital lipodystrophy 0 trials · 1 incl. sub-types Sub-types →
- Keppen-Lubinsky syndrome 0 trials
- SHORT syndrome 0 trials
- Wiedemann-Rautenstrauch syndrome 0 trials
- Lipoatrophy with diabetes, leukomelanodermic papules, liver steatosis, and hypertrophic cardiomyopathy 0 trials
- Lipodystrophy due to peptidic growth factors deficiency 0 trials
- Lipodystrophy-intellectual disability-deafness syndrome 0 trials
- Mandibuloacral dysplasia 0 trials Sub-types →
- Severe neurodegenerative syndrome with lipodystrophy 0 trials
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Generalized lipodystrophy 8 trials · 11 incl. sub-types
2 sub-types
- Congenital generalized lipodystrophy 2 trials · 3 incl. sub-types Sub-types →
- Acquired generalized lipodystrophy 0 trials
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Acquired lipodystrophy 3 trials · 9 incl. sub-types
2 sub-types
- Acquired partial lipodystrophy 6 trials
- Acquired generalized lipodystrophy 0 trials
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Localized lipodystrophy 0 trials · 4 incl. sub-types
5 sub-types
- Drug-induced localized lipodystrophy 2 trials
- Centrifugal lipodystrophy 1 trial
- Panniculitis and localized lipodystrophy 1 trial
- Idiopathic localized lipodystrophy 0 trials
- Pressure-induced localized lipoatrophy 0 trials
Most studied deeper sub-types
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New hope for youngest kids with rare fat disorder
Disease control Stopped earlyThis study tests a drug called metreleptin in 15 children under 6 years old who have a rare disease called generalized lipodystrophy, which prevents the body from storing fat properly and often leads to diabetes and high triglycerides. The goal is to see if the drug can lower blo…
Phase 3 • Sponsor: Amryt Pharma • Aim: Disease control
Last updated Jul 24, 2026 00:00 UTC
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HIV pill combo fails to slim belly fat in early trial
Disease control Stopped earlyThis study tested whether switching to a two-drug HIV treatment (raltegravir plus maraviroc) could reduce belly fat (lipohypertrophy) in people whose HIV was already well-controlled. It included 48 adults on stable HIV therapy for at least 5 years. The study was stopped early, so…
Phase 2 • Sponsor: ANRS, Emerging Infectious Diseases • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Experimental drug targets rare fat Disorder's metabolic woes
Disease control Stopped earlyThis phase 2 trial tested a drug called REGN4461 (mibavademab) in 20 people with familial partial lipodystrophy, a rare condition causing abnormal fat distribution and metabolic problems. The study aimed to see if the drug could lower high triglycerides and improve blood sugar co…
Phase 2 • Sponsor: Regeneron Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Hidden fat lumps may sabotage insulin: new study investigates
Knowledge-focused Stopped earlyThis study looked at whether small, hard-to-see fat lumps under the skin (called subclinical lipohypertrophy) change how insulin is absorbed in people with diabetes. Researchers planned to enroll 20 adults with type 1 or type 2 diabetes who use insulin and had these hidden lumps.…
Sponsor: University of British Columbia • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC