Lethal hemolytic anemia-genital anomalies syndrome

Waters-West syndrome is characterized by the association of lethal non-spherocytic, non-immune hemolytic anemia with abnormalities of the external genitalia (micropenis and hypospadias), flat occiput, dimpled earlobes, deep plantar creases, and increased space between the first and second toes. It has been described only once in two brothers who died a few hours after birth. The second-born infant had massive ascites and hepatosplenomegaly. The mother had two spontaneous abortions (at 6 and 12 weeks gestation) but gave birth to a normal girl, suggesting an autosomal or X-linked recessive mode of inheritance. Although the parents were not known to be consanguineous, they shared a French-Canadian and American Indian ethnic origin.

Also known as: water-West syndrome, hemolytic anaemia lethal congenital nonspherocytic with genital and other abnormalities, hemolytic anemia lethal congenital nonspherocytic with genital and other abnormalities, hemolytic anemia, lethal congenital nonspherocytic, with genital and other abnormalities

9 clinical trials for this condition and its sub-types, 0 tagged with Lethal hemolytic anemia-genital anomalies syndrome itself.