Leber hereditary optic neuropathy
MONDO:0010788Leber's hereditary optic neuropathy (LHON) is a mitochondrial neurodegenerative disease affecting the optic nerve and often characterized by sudden vision loss in young adult carriers.
Also known as: LHON, Leber Hereditary optic atrophy, Leber hereditary optic neuropathy, Leber optic atrophy, Leber’s disease, optic atrophy, Leber type
39 clinical trials for this condition and its sub-types, 18 tagged with Leber hereditary optic neuropathy itself.
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Sub-types of Leber hereditary optic neuropathy
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Leber optic atrophy and dystonia 0 trials
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Could vitamin B3 save sight in rare genetic blindness?
Disease control Not yet recruitingThis early study tests whether high-dose vitamin B3 (nicotinamide) can help preserve or improve vision in people with Leber's hereditary optic neuropathy (LHON), a rare genetic disease that causes sudden vision loss. Researchers will give 13 participants 2 grams of vitamin B3 dai…
Phase 1 • Sponsor: University Hospital, Angers • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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New DNA test could end years of uncertainty for mitochondrial disease patients
Diagnosis Not yet recruitingThis pilot study aims to develop a new digital PCR technique to more accurately diagnose mitochondrial diseases. Researchers will test the method on blood, urine, saliva, and muscle fiber samples from 4 patients. If validated, the technique could be faster and cheaper than curren…
Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Diagnosis
Last updated Jun 27, 2026 12:04 UTC