Lateral sclerosis
MONDO:0018155Primary lateral sclerosis (PLS) is an idiopathic non-familial motor neuron disease characterized by slowly progressive upper motor neuron dysfunction leading to spasticity, mild weakness in voluntary muscle movement, hyperreflexia, and loss of motor speech production.
Also known as: PLS, adult-onset PLS, adult-onset primary lateral sclerosis, primary lateral sclerosis
32 clinical trials for this condition and its sub-types, 24 tagged with Lateral sclerosis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Lateral sclerosis
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Juvenile primary lateral sclerosis 0 trials
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Can a simple Skin-Level electric pulse ease muscle stiffness in a rare neurological disease?
Symptom relief CompletedThis trial asks whether a single 30-minute session of transcutaneous electrical stimulation, applied to the back and abdomen, can reduce muscle spasticity and improve walking in people with primary lateral sclerosis (PLS). Participants will attend one clinic visit, receive the st…
Sponsor: Nova Southeastern University • Aim: Symptom relief
Last updated Aug 27, 2026 00:00 UTC
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Wearable sensors monitor ALS progression in new study
Knowledge-focused CompletedThis study tests whether wearable sensors and digital home tasks can track changes in movement, speech, and falls in people with ALS. About 20 participants will wear neck and wrist sensors and complete speech and handwriting tests over 48 weeks. The goal is to see if these digita…
Sponsor: Milton S. Hershey Medical Center • Aim: Knowledge-focused
Last updated Jul 01, 2026 00:00 UTC
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Tablet tests could track ALS progression through speech and handwriting
Knowledge-focused CompletedThis study explores whether digital tools on a tablet can measure changes in speech and handwriting in people with motor neuron diseases like ALS. Participants complete a single session of speaking and tracing tasks. Researchers compare results between patients and healthy contro…
Sponsor: Milton S. Hershey Medical Center • Aim: Knowledge-focused
Last updated Jul 01, 2026 00:00 UTC
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Remote care trial offers hope for MND patients struggling to reach specialists
Knowledge-focused CompletedThis study tested whether a telehealth system could help people with motor neurone disease (MND) receive specialist care from home, avoiding long trips to the clinic. It involved 40 patients and their caregivers, with half using the system for up to 18 months. The goal was to see…
Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:35 UTC
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Can a simple questionnaire improve spiritual care for the dying?
Knowledge-focused CompletedThis study looked at whether using a Spiritual Needs Questionnaire helps identify and address the spiritual needs of patients in palliative care. About 100 patients with cancer, heart failure, COPD, or ALS took part. The goal was to see if this approach is practical and beneficia…
Sponsor: University Hospital Muenster • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC