Late-onset retinal degeneration
MONDO:0011579Late-onset retinal degeneration is an inherited retinal dystrophy characterized by delayed dark adaptation and nyctalopia and drusen deposits presenting in adulthood, followed by cone and rod degeneration that presents in the sixth decade of life, which leads to central vision loss. Anterior segment features such as peripupillary iris transillumination defects and abnormally long anterior zonular insertions are also observed. Choroidal neovascularization and glaucoma may occur in the late stages of the disease.
Also known as: LORD, autosomal dominant late-onset retinal degeneration, late-onset retinal degeneration, pigmentary retinopathy, retinal Degeneration, late-onset, autosomal dominant
27 clinical trials for this condition and its sub-types, 2 tagged with Late-onset retinal degeneration itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →-
Scientists harvest cells to grow mini retinas in lab
Knowledge-focused Recruiting nowThis study collects skin, hair, blood, urine, or saliva samples from people with certain eye diseases (like macular degeneration) and from healthy volunteers. Researchers will turn these samples into stem cells in the lab to study how the diseases develop and to test potential ne…
Sponsor: National Eye Institute (NEI) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
-
New eye scans could revolutionize how we see retinal disease
Knowledge-focused Recruiting nowThis study uses special cameras to take ultra-detailed pictures of the back of the eye in people with retinal diseases like macular degeneration and retinitis pigmentosa. Researchers aim to develop new ways to diagnose and track these conditions by measuring cell density and func…
Sponsor: Food and Drug Administration (FDA) • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC