Invasive lobular breast carcinoma
MONDO:0005051An infiltrating lobular adenocarcinoma of the breast. The malignant cells lack cohesion and are arranged individually or in a linear manner (Indian files), or as narrow trabeculae within the stroma. The malignant cells are usually smaller than those of ductal carcinoma, are less pleomorphic, and have fewer mitotic figures.
Also known as: lobular carcinoma, lobular carcinoma (morphologic abnormality), lobular carcinoma NOS (morphologic abnormality), lobular carcinoma of the breast, classic invasive lobular carcinoma, infiltrating lobular adenocarcinoma, infiltrating lobular breast carcinoma, infiltrating lobular carcinoma of breast
2827 clinical trials for this condition and its sub-types, 30 tagged with Invasive lobular breast carcinoma itself.
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Custom-Made cancer vaccine shows promise in advanced tumors
Disease control Recruiting nowThis study tests a personalized vaccine made from a patient's own tumor proteins, given alone or with the immunotherapy drug pembrolizumab. The goal is to see if the combination is safe and helps the immune system attack advanced solid tumors. About 132 people with various advanc…
Phase 1/2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
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New drug combo shows promise for rare breast cancer type
Disease control Recruiting nowThis phase II trial is testing whether the drug neratinib, given before standard treatment, can improve outcomes for people with stage I-III HER2-mutated lobular breast cancer. Neratinib blocks a protein that helps cancer cells grow. The study will enroll 30 participants and meas…
Phase 2 • Sponsor: Vanderbilt-Ingram Cancer Center • Aim: Disease control
Last updated Aug 21, 2026 00:00 UTC
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New hope for Hard-to-Treat lobular breast cancer?
Disease control Recruiting nowThis phase 2 trial is testing a drug called ivonescimab in people with a specific type of breast cancer called invasive lobular carcinoma that has spread and no longer responds to hormone therapy. The study includes 29 adults whose cancer is either hormone-receptor positive or tr…
Phase 2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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Can Pre-Surgery hormone therapy help lobular breast cancer patients?
Disease control Recruiting nowThis study looks at whether giving hormone therapy before breast-conserving surgery helps reduce leftover cancer cells at the edges of removed tissue. It involves 176 postmenopausal women with stage 2-3 ER+/HER2- invasive lobular carcinoma. The goal is to see if this approach lea…
Phase 2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
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New short radiation regimen aims to cut side effects in breast cancer treatment
Disease control Recruiting nowThis study is testing whether a shorter, higher-dose radiation treatment (APBI) given over just three days is safe and effective for women with early-stage breast cancer or DCIS who have had a lumpectomy. The goal is to see if this approach causes fewer or milder side effects com…
Phase 2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Jun 26, 2026 17:32 UTC
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New PET tracer aims to spot hidden cancer spread in the abdomen
Diagnosis Recruiting nowThis phase 2 study tests whether a radioactive tracer called [68Ga]BED003 can improve PET/CT scans for detecting cancer in the peritoneum (the lining of the abdomen). The trial includes adults with colorectal, ovarian, gastric, pancreatic, or a type of breast cancer. Researchers …
Phase 2 • Sponsor: Blue Earth Diagnostics • Aim: Diagnosis
Last updated Sep 17, 2026 00:00 UTC
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New scan could spot Hard-to-Find breast cancer spread
Diagnosis Recruiting nowThis early-stage trial tests a new radioactive tracer called [68Ga]Ga DOTA-5G for PET/CT scans in 30 people with metastatic lobular breast cancer. The goal is to see if it can find cancer lesions better than current methods and to check its safety. Participants receive one inject…
Phase 1 • Sponsor: University of California, Davis • Aim: Diagnosis
Last updated Sep 16, 2026 00:00 UTC
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New PET tracer could sharpen cancer detection
Diagnosis Recruiting nowThis study tests a new radioactive tracer called [18F]FPyQCP for PET scans to see if it can better detect several cancers, including colorectal, ovarian, gastric, breast, and pancreatic. About 71 adults with these cancers will receive the tracer and have a PET/CT scan. The goal i…
Phase 1/2 • Sponsor: Blue Earth Diagnostics • Aim: Diagnosis
Last updated Jun 27, 2026 14:01 UTC
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Could a scan replace surgery for breast cancer staging?
Diagnosis Recruiting nowThis study tests whether a special PET/MRI scan can accurately detect if breast cancer has spread to lymph nodes in the armpit, potentially replacing the need for surgical removal of those nodes. About 119 women with certain types of breast cancer (luminal A or lobular) will get …
Phase 2 • Sponsor: Università Vita-Salute San Raffaele • Aim: Diagnosis
Last updated Jun 27, 2026 13:06 UTC
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New radiation method may boost immune attack on tumors
Symptom relief Recruiting nowThis study compares a new radiation technique called lattice radiation therapy (LRT) to standard stereotactic body radiation therapy (SBRT) for people with solid tumors that have spread to soft tissues. The goal is to see if LRT shrinks tumors better and helps the immune system f…
Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Symptom relief
Last updated Sep 04, 2026 00:00 UTC
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Scientists investigate rare breast cancer subtype to improve future care
Knowledge-focused Recruiting nowThis study looks back at medical records of 250 people with a rare type of breast cancer called apocrine lobular carcinoma. Researchers want to understand how this cancer behaves, what treatments patients received, and how they did over time. No new treatments are tested — the go…
Sponsor: Istituto Oncologico Veneto IRCCS • Aim: Knowledge-focused
Last updated Sep 04, 2026 00:00 UTC
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New registry hopes to unlock secrets of rare breast cancer
Knowledge-focused Recruiting nowThis study is creating a registry for people with a rare type of breast cancer called invasive lobular carcinoma that has spread. Researchers will collect data from about 12 participants to develop a new tool that better measures how well treatments are working. The goal is to im…
Sponsor: University of California, San Francisco • Aim: Knowledge-focused
Last updated Sep 04, 2026 00:00 UTC
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New tests could predict if breast cancer therapy is working
Knowledge-focused Recruiting nowThis pilot study is looking for better ways to see if endocrine therapy is working in people with a type of breast cancer called metastatic invasive lobular carcinoma. Researchers will use a special PET scan and blood tests to measure changes in estrogen signaling after 4 weeks o…
Phase 2 • Sponsor: University of Wisconsin, Madison • Aim: Knowledge-focused
Last updated Aug 27, 2026 00:00 UTC
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Can mapping tumor DNA unlock personalized breast cancer care?
Knowledge-focused Recruiting nowThe AURORA study is collecting tumor and blood samples from 1,300 people with metastatic breast cancer across Europe. By analyzing genetic changes in both the original and metastatic tumors, researchers hope to understand why some patients respond well to therapy while others do …
Sponsor: Jules Bordet Institute • Aim: Knowledge-focused
Last updated Aug 08, 2026 00:03 UTC
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Blood test could Fine-Tune breast cancer therapy
Knowledge-focused Recruiting nowThis study explores whether a liquid biopsy (a blood test that detects tumor DNA) can help doctors adjust treatment early for people with metastatic lobular breast cancer. About 20 participants will have their blood tested regularly while on standard hormone therapy. The goal is …
Sponsor: Julia Foldi • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC